TY - JOUR
T1 - T1 signal intensity ratio of the pancreas as an imaging biomarker for the staging of chronic pancreatitis
AU - Tirkes, Temel
AU - Dasyam, Anil K.
AU - Shah, Zarine K.
AU - Fogel, Evan L.
AU - Vege, Santhi Swaroop
AU - Li, Liang
AU - Li, Shuang
AU - Chang, Stephanie T.
AU - Farinas, Carlos A.
AU - Grajo, Joseph R.
AU - Mawad, Kareem
AU - Takahashi, Naoki
AU - Venkatesh, Sudhakar K.
AU - Wachsman, Ashley
AU - Fisher, William E.
AU - Forsmark, Christopher E.
AU - Hart, Phil A.
AU - Pandol, Stephen J.
AU - Park, Walter G.
AU - Van Den Eeden, Stephen K.
AU - Yang, Yunlong
AU - Topazian, Mark
AU - Andersen, Dana K.
AU - Serrano, Jose
AU - Conwell, Darwin L.
AU - Yadav, Dhiraj
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/10
Y1 - 2022/10
N2 - Purpose: Our purpose was to validate the T1 SIR (T1 score) as an imaging biomarker for the staging of CP in a large, multi-institutional, prospective study. Methods: The prospective study population included 820 participants enrolled in the PROCEED study from nine clinical centers between June 2017 and December 2021. A radiologist at each institution used a standardized method to measure the T1 signal intensity of the pancreas and the reference organs (spleen, paraspinal muscle, liver), which was used to derive respective T1 scores. Participants were stratified according to the seven mechanistic stages of chronic pancreatitis (MSCP 0–6) based on their clinical history, MRCP, and CT findings. Results: The mean pancreas-to-spleen T1 score was 1.30 in participants with chronic abdominal pain, 1.22 in those with acute or recurrent acute pancreatitis, and 1.03 in definite CP. After adjusting for covariates, we observed a linear, progressive decline in the pancreas-to-spleen T1 score with increasing MSCP from 0 to 6. The mean pancreas-to-spleen T1 scores were 1.34 (MSCP 0), 1.27 (MSCP 1), 1.21 (MSCP 2), 1.16 (MSCP 3), 1.18 (MSCP 4), 1.12 (MSCP 5), and 1.05 (MSCP 6) (p < 0.0001). The pancreas-to-liver and pancreas-to-muscle T1 scores showed less linear trends and wider confidence intervals. Conclusion: The T1 score calculated by SIR of the pancreas-to-spleen shows a negative linear correlation with the progression of chronic pancreatitis. It holds promise as a practical imaging biomarker in evaluating disease severity in clinical research and practice. Graphical abstract: [Figure not available: see fulltext.].
AB - Purpose: Our purpose was to validate the T1 SIR (T1 score) as an imaging biomarker for the staging of CP in a large, multi-institutional, prospective study. Methods: The prospective study population included 820 participants enrolled in the PROCEED study from nine clinical centers between June 2017 and December 2021. A radiologist at each institution used a standardized method to measure the T1 signal intensity of the pancreas and the reference organs (spleen, paraspinal muscle, liver), which was used to derive respective T1 scores. Participants were stratified according to the seven mechanistic stages of chronic pancreatitis (MSCP 0–6) based on their clinical history, MRCP, and CT findings. Results: The mean pancreas-to-spleen T1 score was 1.30 in participants with chronic abdominal pain, 1.22 in those with acute or recurrent acute pancreatitis, and 1.03 in definite CP. After adjusting for covariates, we observed a linear, progressive decline in the pancreas-to-spleen T1 score with increasing MSCP from 0 to 6. The mean pancreas-to-spleen T1 scores were 1.34 (MSCP 0), 1.27 (MSCP 1), 1.21 (MSCP 2), 1.16 (MSCP 3), 1.18 (MSCP 4), 1.12 (MSCP 5), and 1.05 (MSCP 6) (p < 0.0001). The pancreas-to-liver and pancreas-to-muscle T1 scores showed less linear trends and wider confidence intervals. Conclusion: The T1 score calculated by SIR of the pancreas-to-spleen shows a negative linear correlation with the progression of chronic pancreatitis. It holds promise as a practical imaging biomarker in evaluating disease severity in clinical research and practice. Graphical abstract: [Figure not available: see fulltext.].
KW - MRI
KW - Mechanistic Stages of Chronic Pancreatitis
KW - T1 score
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U2 - 10.1007/s00261-022-03611-4
DO - 10.1007/s00261-022-03611-4
M3 - Article
C2 - 35857066
AN - SCOPUS:85134579854
SN - 2366-004X
VL - 47
SP - 3507
EP - 3519
JO - Abdominal Radiology
JF - Abdominal Radiology
IS - 10
ER -