T1-T2 carcinoma of the glottis: Relative hypofractionation

Marcus E. Randall, Donna J. Springer, Milton Raben

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Radiation therapy, the preferred primary treatment for early squamous cell carcinoma of the glottis, offers high local control rates with voice preservation; however, the optimal treatment schedule is subject to debate. Local control, with and without surgical salvage, and associated long-term effects and complications were retrospectively analyzed in 90 patients treated with definitive radiation therapy for T1-T2 squamous cell carcinoma of the glottis. Patients received three weekly fractions of 333 cGy to a total dose of 60 Gy in 6 weeks. Median follow-up was 51.5 months. With radiation therapy alone, local control was 92% for T1 disease and 88% for T2; with surgical salvage, the control rate was 99%. Long-term effects included moderate hoarseness (16% of patients) and moderate or severe laryngeal edema (10% of patients). In seven patients who underwent salvage surgery, the complication rate was 29%. Despite excellent local control, this regimen may produce more long-term effects and complications than conventional fractionation.

Original languageEnglish
Pages (from-to)569-571
Number of pages3
Issue number2
StatePublished - May 1991


  • Larynx, neoplasms, 271.373
  • Larynx, surgery
  • Larynx, therapeutic radiology, 371.1299
  • Neoplasms, therapeutic radiology
  • Radiations, injurious effects, complications of therapeutic radiology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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