Abstract
Recent discoveries on virus-driven hijacking and compartmentalization of the cellular glycolytic and fermentation pathways to support robust virus replication put the spotlight on the energy requirement of viral processes. The active recruitment of glycolytic enzymes in combination with fermentation enzymes by the viral replication proteins emphasizes the advantages of producing ATP locally within viral replication structures. This leads to a paradigm shift in our understanding of how viruses take over host metabolism to support the virus’s energy needs during the replication process. This review highlights our current understanding of how a small plant virus, Tomato bushy stunt virus, exploits a conserved energy-generating cellular pathway during viral replication. The emerging picture is that viruses not only rewire cellular metabolic pathways to obtain the necessary resources from the infected cells but the fast replicating viruses might have to actively hijack and compartmentalize the energy-producing enzymes to provide a readily available source of ATP for viral replication process.
| Original language | English |
|---|---|
| Article number | 56 |
| Journal | Viruses |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 3 2020 |
Bibliographical note
Funding Information:Funding: This work was supported by the National Science Foundation (MCB-1517751 and IOS-1922895) and a USDA hatch grant (KY012042) to P.D.N.
Funding Information:
This work was supported by the National Science Foundation (MCB-1517751 and IOS-1922895) and a USDA hatch grant (KY012042) to P.D.N. The authors thank Judit Pogany, Melissa Molho, and Paulina Alatriste Gonzalez for valuable comments on the manuscript.
Publisher Copyright:
© 2020 by the authors.
Keywords
- ATP
- Fermentation
- Glycolysis
- Plant
- Tomato bushy stunt virus
- Virus replication
- Virus-host interactions
- Yeast
ASJC Scopus subject areas
- Infectious Diseases
- Virology
