Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne

Graham B. Jones; Michael W. Kilgore; Richard S. Pollenz; Aiwen Li; Jude E. Mathews; Justin M. Wright; Robert S. Huber; Patricia L. Tate; Thomas L. Price; Robert P. Sticca

doi:10.1016/0960-894X(96)00352-6

Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne

Graham B. Jones
, Michael W. Kilgore
, Richard S. Pollenz
, Aiwen Li
, Jude E. Mathews
, Justin M. Wright
, Robert S. Huber
, Patricia L. Tate
, Thomas L. Price
, Robert P. Sticca

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.

Original language	English
Pages (from-to)	1971-1976
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	16
DOIs	https://doi.org/10.1016/0960-894X(96)00352-6
State	Published - Aug 20 1996

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0960-894X(96)00352-6

Cite this

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title = "Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne",

abstract = "An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.",

author = "Jones, \{Graham B.\} and Kilgore, \{Michael W.\} and Pollenz, \{Richard S.\} and Aiwen Li and Mathews, \{Jude E.\} and Wright, \{Justin M.\} and Huber, \{Robert S.\} and Tate, \{Patricia L.\} and Price, \{Thomas L.\} and Sticca, \{Robert P.\}",

year = "1996",

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doi = "10.1016/0960-894X(96)00352-6",

language = "English",

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T1 - Target directed enediyne prodrugs

T2 - hER and AhR degradation by a synthetic oxo-enediyne

AU - Jones, Graham B.

AU - Kilgore, Michael W.

AU - Pollenz, Richard S.

AU - Li, Aiwen

AU - Mathews, Jude E.

AU - Wright, Justin M.

AU - Huber, Robert S.

AU - Tate, Patricia L.

AU - Price, Thomas L.

AU - Sticca, Robert P.

PY - 1996/8/20

Y1 - 1996/8/20

N2 - An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.

AB - An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.

UR - https://www.scopus.com/pages/publications/0030594975

UR - https://www.scopus.com/pages/publications/0030594975#tab=citedBy

U2 - 10.1016/0960-894X(96)00352-6

DO - 10.1016/0960-894X(96)00352-6

M3 - Article

AN - SCOPUS:0030594975

SN - 0960-894X

VL - 6

SP - 1971

EP - 1976

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne

Abstract

UN SDGs

ASJC Scopus subject areas

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