Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne

Graham B. Jones; Michael W. Kilgore; Richard S. Pollenz; Aiwen Li; Jude E. Mathews; Justin M. Wright; Robert S. Huber; Patricia L. Tate; Thomas L. Price; Robert P. Sticca

doi:10.1016/0960-894X(96)00352-6

Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne

Graham B. Jones, Michael W. Kilgore, Richard S. Pollenz, Aiwen Li, Jude E. Mathews, Justin M. Wright, Robert S. Huber, Patricia L. Tate, Thomas L. Price, Robert P. Sticca

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.

Original language	English
Pages (from-to)	1971-1976
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	16
DOIs	https://doi.org/10.1016/0960-894X(96)00352-6
State	Published - Aug 20 1996

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0960-894X(96)00352-6

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title = "Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne",

abstract = "An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.",

author = "Jones, \{Graham B.\} and Kilgore, \{Michael W.\} and Pollenz, \{Richard S.\} and Aiwen Li and Mathews, \{Jude E.\} and Wright, \{Justin M.\} and Huber, \{Robert S.\} and Tate, \{Patricia L.\} and Price, \{Thomas L.\} and Sticca, \{Robert P.\}",

year = "1996",

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T1 - Target directed enediyne prodrugs

T2 - hER and AhR degradation by a synthetic oxo-enediyne

AU - Jones, Graham B.

AU - Kilgore, Michael W.

AU - Pollenz, Richard S.

AU - Li, Aiwen

AU - Mathews, Jude E.

AU - Wright, Justin M.

AU - Huber, Robert S.

AU - Tate, Patricia L.

AU - Price, Thomas L.

AU - Sticca, Robert P.

PY - 1996/8/20

Y1 - 1996/8/20

N2 - An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.

AB - An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.

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U2 - 10.1016/0960-894X(96)00352-6

DO - 10.1016/0960-894X(96)00352-6

M3 - Article

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne

Abstract

ASJC Scopus subject areas

UN SDGs

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