TY - JOUR
T1 - Targeted therapies in colorectal cancer
T2 - Surgical considerations
AU - Luu, Carrie
AU - Arrington, Amanda K.
AU - Schoellhammer, Hans F.
AU - Singh, Gagandeep
AU - Kim, Joseph
PY - 2013/9
Y1 - 2013/9
N2 - Colorectal cancer (CRC) is a leading worldwide health concern that is responsible for thousands of deaths each year. The primary source of mortality for patients with CRC is the development and subsequent progression of metastatic disease. The most common site for distant metastatic disease is the liver. Although patients with metastatic disease to the liver have several effective treatment options, the only one for cure remains surgical resection of the liver metastases. Historically, most patients with liver metastases have had unresectable disease, and only a small percentage of patients have undergone complete curative resection. However, improved systemic therapies have led to an evolution in strategies to treat metastatic CRC to the liver. Under most conditions the management of these patients remains complex; and as chemotherapy options and new targeted therapies continue to improve outcomes, it is clear that a multidisciplinary approach must be the foundation on which advanced surgical and medical techniques are employed. Here, in this review, we highlight the role of targeted therapies in the surgical management of patients with metastatic CRC to the liver.
AB - Colorectal cancer (CRC) is a leading worldwide health concern that is responsible for thousands of deaths each year. The primary source of mortality for patients with CRC is the development and subsequent progression of metastatic disease. The most common site for distant metastatic disease is the liver. Although patients with metastatic disease to the liver have several effective treatment options, the only one for cure remains surgical resection of the liver metastases. Historically, most patients with liver metastases have had unresectable disease, and only a small percentage of patients have undergone complete curative resection. However, improved systemic therapies have led to an evolution in strategies to treat metastatic CRC to the liver. Under most conditions the management of these patients remains complex; and as chemotherapy options and new targeted therapies continue to improve outcomes, it is clear that a multidisciplinary approach must be the foundation on which advanced surgical and medical techniques are employed. Here, in this review, we highlight the role of targeted therapies in the surgical management of patients with metastatic CRC to the liver.
KW - Chemotherapy
KW - Colorectal cancer (CRC)
KW - Liver
KW - Metastatic colorectal cancer (mCRC)
KW - Surgical management
KW - Targeted therapies
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U2 - 10.3978/j.issn.2078-6891.2013.032
DO - 10.3978/j.issn.2078-6891.2013.032
M3 - Review article
AN - SCOPUS:84995810487
SN - 2078-6891
VL - 4
SP - 328
EP - 336
JO - Journal of Gastrointestinal Oncology
JF - Journal of Gastrointestinal Oncology
IS - 3
ER -