Targeting DNA repair in precision medicine

Reena Beggs, Eddy S. Yang

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

9 Scopus citations


Precision medicine is an emerging treatment paradigm that aims to find the right therapy at the right time based on an individual's unique genetic background, environment, and lifestyle. One area of precision medicine that has had success is targeting DNA repair in cancer. DNA is exposed to constant stress and there are repair mechanisms in place to maintain genetic integrity. These repair mechanisms can be targeted as a treatment strategy. In this chapter, we will focus on current efforts to target DNA repair pathways as part of precision oncology-based treatments.

Original languageEnglish
Title of host publicationAdvances in Protein Chemistry and Structural Biology
Number of pages21
StatePublished - Jan 1 2019

Publication series

NameAdvances in Protein Chemistry and Structural Biology
ISSN (Print)1876-1623

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.


  • DNA damage
  • DNA repair
  • Homologous recombination
  • PARP
  • Personalized medicine
  • Precision medicine
  • Targeted therapy

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry


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