Abstract
Precision medicine is an emerging treatment paradigm that aims to find the right therapy at the right time based on an individual's unique genetic background, environment, and lifestyle. One area of precision medicine that has had success is targeting DNA repair in cancer. DNA is exposed to constant stress and there are repair mechanisms in place to maintain genetic integrity. These repair mechanisms can be targeted as a treatment strategy. In this chapter, we will focus on current efforts to target DNA repair pathways as part of precision oncology-based treatments.
| Original language | English |
|---|---|
| Title of host publication | Advances in Protein Chemistry and Structural Biology |
| Pages | 135-155 |
| Number of pages | 21 |
| DOIs | |
| State | Published - Jan 1 2019 |
Publication series
| Name | Advances in Protein Chemistry and Structural Biology |
|---|---|
| Volume | 115 |
| ISSN (Print) | 1876-1623 |
Bibliographical note
Publisher Copyright:© 2019 Elsevier Inc.
Keywords
- DNA damage
- DNA repair
- Homologous recombination
- PARP
- Personalized medicine
- Precision medicine
- Targeted therapy
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
