Targeting drug transporter Mrp4 increases topotecan accumulation in the CNS

Markos Leggas, Masashi Adachi, Daxi Sun, Guoqing Du, Kelly E. Mercer, Yanli Zhuang, John C. Panetta, Brad Johnston, Clinton F. Stewart, George L. Scheffer, Rik J. Scheper, Peter Wielinga

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Pharmacology, Toxicology and Pharmaceutical Science