Targeting the spliceosome

Brian Rymond

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations


The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP block splicing and prompt nuclear export of intron-bearing precursors, defining a new mode of action in anticancer drugs.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalNature Chemical Biology
Issue number9
StatePublished - Sep 2007

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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