Abstract
The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP block splicing and prompt nuclear export of intron-bearing precursors, defining a new mode of action in anticancer drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 533-535 |
| Number of pages | 3 |
| Journal | Nature Chemical Biology |
| Volume | 3 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2007 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology