Tbx3-Mediated Regulation of Cardiac Conduction System Development and Function: Potential Contributions of Alternative RNA Processing

Brian P. Delisle; Yao Yu; Pavan Puvvula; Allison R. Hall; Chad Huff; Anne M. Moon

doi:10.1007/s00246-019-02166-4

Tbx3-Mediated Regulation of Cardiac Conduction System Development and Function: Potential Contributions of Alternative RNA Processing

Brian P. Delisle, Yao Yu, Pavan Puvvula, Allison R. Hall, Chad Huff, Anne M. Moon

Physiology

Research output: Contribution to journal › Article › peer-review

Abstract

In this article, we provide a brief summary of work by us and others to discover the molecular underpinnings of early conduction system development and function. We focus on how the multifunctional protein Tbx3 contributes to acquisition and homeostasis of the tissue-specific properties of the sinoatrial and atrioventricular nodes. We also provide unpublished, preliminary findings supporting the role of Tbx3-regulated alternative RNA processing in the developing conduction system.

Original language	English
Pages (from-to)	1388-1400
Number of pages	13
Journal	Pediatric Cardiology
Volume	40
Issue number	7
DOIs	https://doi.org/10.1007/s00246-019-02166-4
State	Published - Oct 1 2019

Bibliographical note

Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Channelopathies
Conduction system
Development
Tbx3

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Cardiology and Cardiovascular Medicine

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10.1007/s00246-019-02166-4

Cite this

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AU - Huff, Chad

AU - Moon, Anne M.

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Tbx3-Mediated Regulation of Cardiac Conduction System Development and Function: Potential Contributions of Alternative RNA Processing

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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