TY - JOUR
T1 - Telomerase activity is elevated in early S phase in hamster cells
AU - Kruk, Patricia A.
AU - Orren, David K.
AU - Bohr, Vilhelm A.
PY - 1997/4/28
Y1 - 1997/4/28
N2 - Telomerase is a ribonucleoprotein that elongates telomeric repeats de novo. We examined the possibility that telomerase activity is cell cycle regulated by examining telomerase activity in cell cycle synchronized Chinese hamster ovary (CHO) B11 cells. Overall telomerase activity was similar in growing and quiescent cells. Further, cells synchronized in G1, S, or G2/M showed similar levels of telomerase activity. However, a detailed analysis of cells within S phase showed that there was a higher level of telomerase activity in early S phase when compared with other points in the cell cycle. These results suggest a relationship between telomerase activity and cell cycle regulation.
AB - Telomerase is a ribonucleoprotein that elongates telomeric repeats de novo. We examined the possibility that telomerase activity is cell cycle regulated by examining telomerase activity in cell cycle synchronized Chinese hamster ovary (CHO) B11 cells. Overall telomerase activity was similar in growing and quiescent cells. Further, cells synchronized in G1, S, or G2/M showed similar levels of telomerase activity. However, a detailed analysis of cells within S phase showed that there was a higher level of telomerase activity in early S phase when compared with other points in the cell cycle. These results suggest a relationship between telomerase activity and cell cycle regulation.
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U2 - 10.1006/bbrc.1997.6549
DO - 10.1006/bbrc.1997.6549
M3 - Article
C2 - 9168921
AN - SCOPUS:0031589209
SN - 0006-291X
VL - 233
SP - 717
EP - 722
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -