Temperature Sensitivity of Two-Pore (K2P) Potassium Channels

Eve R. Schneider, Evan O. Anderson, Elena O. Gracheva, Sviatoslav N. Bagriantsev

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

45 Scopus citations

Abstract

At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. This review focuses on the current understanding of the physiological role of heat-activated K2P current, and discusses the molecular mechanism of temperature gating in TREK-1, TREK-2, and TRAAK.

Original languageEnglish
Title of host publicationCurrent Topics in Membranes
Pages113-133
Number of pages21
Edition1
DOIs
StatePublished - 2014

Publication series

NameCurrent Topics in Membranes
Number1
Volume74
ISSN (Print)1063-5823

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Inc.

Keywords

  • Ion channel
  • K
  • Potassium channel
  • TRAAK
  • TREK-1
  • TREK-2
  • Thermosensitivity
  • Thermotransduction
  • Two-pore

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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