Temperature Sensitivity of Two-Pore (K2P) Potassium Channels

Eve R. Schneider, Evan O. Anderson, Elena O. Gracheva, Sviatoslav N. Bagriantsev

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

39 Scopus citations


At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. This review focuses on the current understanding of the physiological role of heat-activated K2P current, and discusses the molecular mechanism of temperature gating in TREK-1, TREK-2, and TRAAK.

Original languageEnglish
Title of host publicationCurrent Topics in Membranes
Number of pages21
StatePublished - 2014

Publication series

NameCurrent Topics in Membranes
ISSN (Print)1063-5823

Bibliographical note

Funding Information:
We thank Willem Laursen for comments on the manuscript. This work was supported by a grant from the American Heart Association (14SDG17880015) to S.N.B., and by fellowships from the Beckman Foundation and Alfred P. Sloan Foundation to E.O.G. Correspondence should be addressed to S.N.B. ( sviatoslav.bagriantsev@yale.edu ).

Publisher Copyright:
© 2014 Elsevier Inc.


  • Ion channel
  • K
  • Potassium channel
  • TREK-1
  • TREK-2
  • Thermosensitivity
  • Thermotransduction
  • Two-pore

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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