TY - JOUR
T1 - Temporal and regional expression of Fos-related proteins in response to ischemic injury
AU - Butler, Tanya L.
AU - Pennypacker, Keith R.
PY - 2004/3/1
Y1 - 2004/3/1
N2 - The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for controlling neuroprotective gene expression. This study characterized the temporal and regional expression of a variety of proteins following ischemic injury induced by occlusion of the middle cerebral artery in rats. The results demonstrated upregulation of both c-Fos and FRA-2 in penumbral regions that preceded upregulation of the classic injury-associated proteins expressed by astrocytes and microglia and, in the case of FRA-2, appeared to correlate with neuronal survival. A further, previously undescribed, expression of FRA-2 in endothelial cells of the core ischemic region was also demonstrated.
AB - The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for controlling neuroprotective gene expression. This study characterized the temporal and regional expression of a variety of proteins following ischemic injury induced by occlusion of the middle cerebral artery in rats. The results demonstrated upregulation of both c-Fos and FRA-2 in penumbral regions that preceded upregulation of the classic injury-associated proteins expressed by astrocytes and microglia and, in the case of FRA-2, appeared to correlate with neuronal survival. A further, previously undescribed, expression of FRA-2 in endothelial cells of the core ischemic region was also demonstrated.
KW - AP-1
KW - FRA-2
KW - MCAO
KW - Neuroprotection
KW - Stroke
KW - c-Fos
UR - http://www.scopus.com/inward/record.url?scp=2342634555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2342634555&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2003.12.005
DO - 10.1016/j.brainresbull.2003.12.005
M3 - Article
C2 - 15121240
AN - SCOPUS:2342634555
SN - 0361-9230
VL - 63
SP - 65
EP - 73
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 1
ER -