Temporal Changes in Infarct Material Properties: An In Vivo Assessment Using Magnetic Resonance Imaging and Finite Element Simulations

Jeremy R. McGarvey, Dimitri Mojsejenko, Shauna M. Dorsey, Amir Nikou, Jason A. Burdick, Joseph H. Gorman, Benjamin M. Jackson, James J. Pilla, Robert C. Gorman, Jonathan F. Wenk

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Background. Infarct expansion initiates and sustains adverse left ventricular (LV) remodeling after myocardial infarction (MI) and is influenced by temporal changes in infarct material properties. Data from ex vivo biaxial extension testing support this hypothesis; however, infarct material properties have never been measured in vivo. The goal of the current study was to serially quantify the in vivo material properties and fiber orientation of infarcted myocardium over a 12-week period in a porcine model of MI. Methods. A combination of magnetic resonance imaging (MRI), catheterization, finite element modeling, and numeric optimization was used to analyze posterolateral MI. Specifically, properties were determined by minimizing the difference between in vivo strains and volume calculated from MRI and strains and volume predicted by finite element modeling. Results. In 1 week after MI, the infarct region was found to be approximately 20 times stiffer than normal diastolic myocardium. Over the course of 12 weeks, the infarct region became progressively less stiff as the LV dilated and ejection fraction decreased. The infarct thinned by nearly half during the remodeling period, and infarct fiber angles became more circumferentially oriented. Conclusions. The results reported here are consistent with previously described ex vivo biaxial extension studies of infarct material properties and the circumferential change of collagen orientation in posterolateral infarcts. The current study represents a significant advance in that the method used allows for the serial assessment of an individual infarct in vivo over time and avoids the inherent limitations related to the testing of excised tissues.

Original languageEnglish
Pages (from-to)582-589
Number of pages8
JournalAnnals of Thoracic Surgery
Volume100
Issue number2
DOIs
StatePublished - Aug 1 2015

Bibliographical note

Publisher Copyright:
© 2015 by The Society of Thoracic Surgeons.

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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