Temporal distribution of endogenous retinoids in the embryonic mouse mandible

Cynthia S. Beeman; Jan E. Kronmiller

doi:10.1016/0003-9969(94)90001-9

Temporal distribution of endogenous retinoids in the embryonic mouse mandible

Cynthia S. Beeman, Jan E. Kronmiller

Oral Health Science

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Retinoids play an important part in embryonic pattern formation. They are necessary for normal differentiation of odontogenic tissues and, in excess, disrupt the pattern of tooth formation. Excess retinoids produce supernumerary buds of the dental lamina in the diastema region of the mouse embryonic mandible where teeth do not normally form. This effect is coincident with an increase in epithelial proliferation and an alteration in epidermal growth factor mRNA expression (a gene product necessary for tooth formation). It was found by high-performance liquid chromatography that endogenous retinoids are present in the developing murine mandible and that concentrations of some retinoids reach a peak at the time of the initiation of odontogenesis (dental lamina formation).

Original language	English
Pages (from-to)	733-739
Number of pages	7
Journal	Archives of Oral Biology
Volume	39
Issue number	9
DOIs	https://doi.org/10.1016/0003-9969(94)90001-9
State	Published - Sep 1994

Bibliographical note

Funding Information:
Acknowledgement-This work was supported in part by a grant from the American Association of Orthodontists (JEK/SCB).

Funding

Acknowledgement-This work was supported in part by a grant from the American Association of Orthodontists (JEK/SCB).

Funders	Funder number
American Association of Orthodontists

Keywords

HPLC
embryonic
endogenous murine
mandible
retinoids

ASJC Scopus subject areas

Otorhinolaryngology
General Dentistry
Cell Biology

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10.1016/0003-9969(94)90001-9

Cite this

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title = "Temporal distribution of endogenous retinoids in the embryonic mouse mandible",

abstract = "Retinoids play an important part in embryonic pattern formation. They are necessary for normal differentiation of odontogenic tissues and, in excess, disrupt the pattern of tooth formation. Excess retinoids produce supernumerary buds of the dental lamina in the diastema region of the mouse embryonic mandible where teeth do not normally form. This effect is coincident with an increase in epithelial proliferation and an alteration in epidermal growth factor mRNA expression (a gene product necessary for tooth formation). It was found by high-performance liquid chromatography that endogenous retinoids are present in the developing murine mandible and that concentrations of some retinoids reach a peak at the time of the initiation of odontogenesis (dental lamina formation).",

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language = "English",

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T1 - Temporal distribution of endogenous retinoids in the embryonic mouse mandible

AU - Beeman, Cynthia S.

AU - Kronmiller, Jan E.

N1 - Funding Information: Acknowledgement-This work was supported in part by a grant from the American Association of Orthodontists (JEK/SCB).

PY - 1994/9

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N2 - Retinoids play an important part in embryonic pattern formation. They are necessary for normal differentiation of odontogenic tissues and, in excess, disrupt the pattern of tooth formation. Excess retinoids produce supernumerary buds of the dental lamina in the diastema region of the mouse embryonic mandible where teeth do not normally form. This effect is coincident with an increase in epithelial proliferation and an alteration in epidermal growth factor mRNA expression (a gene product necessary for tooth formation). It was found by high-performance liquid chromatography that endogenous retinoids are present in the developing murine mandible and that concentrations of some retinoids reach a peak at the time of the initiation of odontogenesis (dental lamina formation).

AB - Retinoids play an important part in embryonic pattern formation. They are necessary for normal differentiation of odontogenic tissues and, in excess, disrupt the pattern of tooth formation. Excess retinoids produce supernumerary buds of the dental lamina in the diastema region of the mouse embryonic mandible where teeth do not normally form. This effect is coincident with an increase in epithelial proliferation and an alteration in epidermal growth factor mRNA expression (a gene product necessary for tooth formation). It was found by high-performance liquid chromatography that endogenous retinoids are present in the developing murine mandible and that concentrations of some retinoids reach a peak at the time of the initiation of odontogenesis (dental lamina formation).

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KW - endogenous murine

KW - mandible

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Temporal distribution of endogenous retinoids in the embryonic mouse mandible

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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