Temporal distribution of endogenous retinoids in the embryonic mouse mandible

Cynthia S. Beeman, Jan E. Kronmiller

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Retinoids play an important part in embryonic pattern formation. They are necessary for normal differentiation of odontogenic tissues and, in excess, disrupt the pattern of tooth formation. Excess retinoids produce supernumerary buds of the dental lamina in the diastema region of the mouse embryonic mandible where teeth do not normally form. This effect is coincident with an increase in epithelial proliferation and an alteration in epidermal growth factor mRNA expression (a gene product necessary for tooth formation). It was found by high-performance liquid chromatography that endogenous retinoids are present in the developing murine mandible and that concentrations of some retinoids reach a peak at the time of the initiation of odontogenesis (dental lamina formation).

Original languageEnglish
Pages (from-to)733-739
Number of pages7
JournalArchives of Oral Biology
Issue number9
StatePublished - Sep 1994

Bibliographical note

Funding Information:
Acknowledgement-This work was supported in part by a grant from the American Association of Orthodontists (JEK/SCB).


  • HPLC
  • embryonic
  • endogenous murine
  • mandible
  • retinoids

ASJC Scopus subject areas

  • Otorhinolaryngology
  • General Dentistry
  • Cell Biology


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