TY - JOUR
T1 - Tenofovir-associated severe bone pain
T2 - I cannot walk!
AU - Jhaveri, Malhar A.
AU - Mawad, Hanna W.
AU - Thornton, Alice C.
AU - Mullen, Nancy W.
AU - Greenberg, Richard N.
PY - 2010/9
Y1 - 2010/9
N2 - Two adult patients living with AIDS presented with severe bone pain associated with tenofovir (TDF) use. Both were unable to walk without assistance and were severely restricted in their movement due to the bone pain. Both had mild renal impairment, Fanconi syndrome, and bone mineral density (BMD) loss. Bone pain and inability to walk were reversible with the cessation of TDF and supplementation with Vitamin D3, calcium, and phosphate. These cases appear to be examples of the severity of BMD loss associated with TDF use and suggest not only attention to renal function with TDF use, but also monitoring of alkaline phosphatase (bone fraction) and plasma phosphorus as indicators of BMD loss.
AB - Two adult patients living with AIDS presented with severe bone pain associated with tenofovir (TDF) use. Both were unable to walk without assistance and were severely restricted in their movement due to the bone pain. Both had mild renal impairment, Fanconi syndrome, and bone mineral density (BMD) loss. Bone pain and inability to walk were reversible with the cessation of TDF and supplementation with Vitamin D3, calcium, and phosphate. These cases appear to be examples of the severity of BMD loss associated with TDF use and suggest not only attention to renal function with TDF use, but also monitoring of alkaline phosphatase (bone fraction) and plasma phosphorus as indicators of BMD loss.
KW - AIDS
KW - bone pain
KW - tenofovir
UR - http://www.scopus.com/inward/record.url?scp=78650802938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650802938&partnerID=8YFLogxK
U2 - 10.1177/1545109710376595
DO - 10.1177/1545109710376595
M3 - Article
C2 - 20923957
AN - SCOPUS:78650802938
SN - 1545-1097
VL - 9
SP - 328
EP - 334
JO - Journal of the International Association of Physicians in AIDS Care
JF - Journal of the International Association of Physicians in AIDS Care
IS - 5
ER -
