Tenofovir-associated severe bone pain: I cannot walk!

Malhar A. Jhaveri, Hanna W. Mawad, Alice C. Thornton, Nancy W. Mullen, Richard N. Greenberg

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Two adult patients living with AIDS presented with severe bone pain associated with tenofovir (TDF) use. Both were unable to walk without assistance and were severely restricted in their movement due to the bone pain. Both had mild renal impairment, Fanconi syndrome, and bone mineral density (BMD) loss. Bone pain and inability to walk were reversible with the cessation of TDF and supplementation with Vitamin D3, calcium, and phosphate. These cases appear to be examples of the severity of BMD loss associated with TDF use and suggest not only attention to renal function with TDF use, but also monitoring of alkaline phosphatase (bone fraction) and plasma phosphorus as indicators of BMD loss.

Original languageEnglish
Pages (from-to)328-334
Number of pages7
JournalJournal of the International Association of Physicians in AIDS Care
Issue number5
StatePublished - Sep 2010


  • AIDS
  • bone pain
  • tenofovir

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases


Dive into the research topics of 'Tenofovir-associated severe bone pain: I cannot walk!'. Together they form a unique fingerprint.

Cite this