Tenofovir-associated severe bone pain: I cannot walk!

Malhar A. Jhaveri; Hanna W. Mawad; Alice C. Thornton; Nancy W. Mullen; Richard N. Greenberg

doi:10.1177/1545109710376595

Tenofovir-associated severe bone pain: I cannot walk!

Malhar A. Jhaveri, Hanna W. Mawad, Alice C. Thornton, Nancy W. Mullen, Richard N. Greenberg

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Two adult patients living with AIDS presented with severe bone pain associated with tenofovir (TDF) use. Both were unable to walk without assistance and were severely restricted in their movement due to the bone pain. Both had mild renal impairment, Fanconi syndrome, and bone mineral density (BMD) loss. Bone pain and inability to walk were reversible with the cessation of TDF and supplementation with Vitamin D₃, calcium, and phosphate. These cases appear to be examples of the severity of BMD loss associated with TDF use and suggest not only attention to renal function with TDF use, but also monitoring of alkaline phosphatase (bone fraction) and plasma phosphorus as indicators of BMD loss.

Original language	English
Pages (from-to)	328-334
Number of pages	7
Journal	Journal of the International Association of Physicians in AIDS Care
Volume	9
Issue number	5
DOIs	https://doi.org/10.1177/1545109710376595
State	Published - Sep 2010

Keywords

AIDS
bone pain
tenofovir

ASJC Scopus subject areas

Immunology
Dermatology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/1545109710376595

Cite this

@article{559dd4f69d3d46b19fa00db8d139da25,

title = "Tenofovir-associated severe bone pain: I cannot walk!",

abstract = "Two adult patients living with AIDS presented with severe bone pain associated with tenofovir (TDF) use. Both were unable to walk without assistance and were severely restricted in their movement due to the bone pain. Both had mild renal impairment, Fanconi syndrome, and bone mineral density (BMD) loss. Bone pain and inability to walk were reversible with the cessation of TDF and supplementation with Vitamin D3, calcium, and phosphate. These cases appear to be examples of the severity of BMD loss associated with TDF use and suggest not only attention to renal function with TDF use, but also monitoring of alkaline phosphatase (bone fraction) and plasma phosphorus as indicators of BMD loss.",

keywords = "AIDS, bone pain, tenofovir",

author = "Jhaveri, {Malhar A.} and Mawad, {Hanna W.} and Thornton, {Alice C.} and Mullen, {Nancy W.} and Greenberg, {Richard N.}",

year = "2010",

month = sep,

doi = "10.1177/1545109710376595",

language = "English",

volume = "9",

pages = "328--334",

number = "5",

}

TY - JOUR

T1 - Tenofovir-associated severe bone pain

T2 - I cannot walk!

AU - Jhaveri, Malhar A.

AU - Mawad, Hanna W.

AU - Thornton, Alice C.

AU - Mullen, Nancy W.

AU - Greenberg, Richard N.

PY - 2010/9

Y1 - 2010/9

N2 - Two adult patients living with AIDS presented with severe bone pain associated with tenofovir (TDF) use. Both were unable to walk without assistance and were severely restricted in their movement due to the bone pain. Both had mild renal impairment, Fanconi syndrome, and bone mineral density (BMD) loss. Bone pain and inability to walk were reversible with the cessation of TDF and supplementation with Vitamin D3, calcium, and phosphate. These cases appear to be examples of the severity of BMD loss associated with TDF use and suggest not only attention to renal function with TDF use, but also monitoring of alkaline phosphatase (bone fraction) and plasma phosphorus as indicators of BMD loss.

AB - Two adult patients living with AIDS presented with severe bone pain associated with tenofovir (TDF) use. Both were unable to walk without assistance and were severely restricted in their movement due to the bone pain. Both had mild renal impairment, Fanconi syndrome, and bone mineral density (BMD) loss. Bone pain and inability to walk were reversible with the cessation of TDF and supplementation with Vitamin D3, calcium, and phosphate. These cases appear to be examples of the severity of BMD loss associated with TDF use and suggest not only attention to renal function with TDF use, but also monitoring of alkaline phosphatase (bone fraction) and plasma phosphorus as indicators of BMD loss.

KW - AIDS

KW - bone pain

KW - tenofovir

UR - http://www.scopus.com/inward/record.url?scp=78650802938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650802938&partnerID=8YFLogxK

U2 - 10.1177/1545109710376595

DO - 10.1177/1545109710376595

M3 - Article

C2 - 20923957

AN - SCOPUS:78650802938

VL - 9

SP - 328

EP - 334

IS - 5

ER -

Tenofovir-associated severe bone pain: I cannot walk!

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this