The acquired immunodeficiency syndrome in intravenous drug abusers and patients with a sexual risk: Clinical and postmortem comparisons

Robert A. Ambros; Eun Young Lee; Leroy R. Sharer; M. Yusuf Khan; Stanley J. Robboy

doi:10.1016/S0046-8177(87)80377-5

The acquired immunodeficiency syndrome in intravenous drug abusers and patients with a sexual risk: Clinical and postmortem comparisons

Robert A. Ambros, Eun Young Lee, Leroy R. Sharer, M. Yusuf Khan, Stanley J. Robboy

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Clinical and necropsy findings in 13 intravenous drug abusers who died of the acquired immunodeficiency syndrome (AIDS) were reviewed and compared with findings in eight patients who acquired the infection through sexual exposure, the most common mode of transmission in AIDS. No differences were found in lymphocyte counts or duration of survival, despite reports that the degree of immunosuppression in intravenous drug abusers with AIDS differs from that in homosexuals. Neoplasms were found in 25 per cent of patients with sexual risks, but not in any drug abusers (0 per cent). Two opportunistic infections (toxoplasmosis and cytomegalovirus pneumonia and esophagitis) were more common in the intravenous drug abuser group. Although cytomegalovirus has been associated with Kaposi's sarcoma, this association was not found in this study. The postmortem findings in both groups were otherwise similar.

Original language	English
Pages (from-to)	1109-1114
Number of pages	6
Journal	Human Pathology
Volume	18
Issue number	11
DOIs	https://doi.org/10.1016/S0046-8177(87)80377-5
State	Published - 1987

Bibliographical note

Funding Information:
From the Department of Pathology. University of Medicine and Dentistry of New jersey-New j ersey Medical School. and University Hospital. Newark. New j ersey. Revision accepted for publication 16 December 1986, Supported in part by grant ROI-AI23242·01 from the National Institutes of Health. Address correspondence and reprintrequests to Dr. Arnbros: Department of Pathology, U:'.IDNj-New Jersey Medical School. 185 South Orange Avenue, Newark, NJ 07103.

Funding

Funders	Funder number
National Institute of Allergy and Infectious Diseases	R01AI023242

ASJC Scopus subject areas

Pathology and Forensic Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0046-8177(87)80377-5

Cite this

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title = "The acquired immunodeficiency syndrome in intravenous drug abusers and patients with a sexual risk: Clinical and postmortem comparisons",

abstract = "Clinical and necropsy findings in 13 intravenous drug abusers who died of the acquired immunodeficiency syndrome (AIDS) were reviewed and compared with findings in eight patients who acquired the infection through sexual exposure, the most common mode of transmission in AIDS. No differences were found in lymphocyte counts or duration of survival, despite reports that the degree of immunosuppression in intravenous drug abusers with AIDS differs from that in homosexuals. Neoplasms were found in 25 per cent of patients with sexual risks, but not in any drug abusers (0 per cent). Two opportunistic infections (toxoplasmosis and cytomegalovirus pneumonia and esophagitis) were more common in the intravenous drug abuser group. Although cytomegalovirus has been associated with Kaposi's sarcoma, this association was not found in this study. The postmortem findings in both groups were otherwise similar.",

author = "Ambros, {Robert A.} and Lee, {Eun Young} and Sharer, {Leroy R.} and Khan, {M. Yusuf} and Robboy, {Stanley J.}",

note = "Funding Information: From the Department of Pathology. University of Medicine and Dentistry of New jersey-New j ersey Medical School. and University Hospital. Newark. New j ersey. Revision accepted for publication 16 December 1986, Supported in part by grant ROI-AI23242·01 from the National Institutes of Health. Address correspondence and reprintrequests to Dr. Arnbros: Department of Pathology, U:'.IDNj-New Jersey Medical School. 185 South Orange Avenue, Newark, NJ 07103.",

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AU - Sharer, Leroy R.

AU - Khan, M. Yusuf

AU - Robboy, Stanley J.

N1 - Funding Information: From the Department of Pathology. University of Medicine and Dentistry of New jersey-New j ersey Medical School. and University Hospital. Newark. New j ersey. Revision accepted for publication 16 December 1986, Supported in part by grant ROI-AI23242·01 from the National Institutes of Health. Address correspondence and reprintrequests to Dr. Arnbros: Department of Pathology, U:'.IDNj-New Jersey Medical School. 185 South Orange Avenue, Newark, NJ 07103.

PY - 1987

Y1 - 1987

N2 - Clinical and necropsy findings in 13 intravenous drug abusers who died of the acquired immunodeficiency syndrome (AIDS) were reviewed and compared with findings in eight patients who acquired the infection through sexual exposure, the most common mode of transmission in AIDS. No differences were found in lymphocyte counts or duration of survival, despite reports that the degree of immunosuppression in intravenous drug abusers with AIDS differs from that in homosexuals. Neoplasms were found in 25 per cent of patients with sexual risks, but not in any drug abusers (0 per cent). Two opportunistic infections (toxoplasmosis and cytomegalovirus pneumonia and esophagitis) were more common in the intravenous drug abuser group. Although cytomegalovirus has been associated with Kaposi's sarcoma, this association was not found in this study. The postmortem findings in both groups were otherwise similar.

AB - Clinical and necropsy findings in 13 intravenous drug abusers who died of the acquired immunodeficiency syndrome (AIDS) were reviewed and compared with findings in eight patients who acquired the infection through sexual exposure, the most common mode of transmission in AIDS. No differences were found in lymphocyte counts or duration of survival, despite reports that the degree of immunosuppression in intravenous drug abusers with AIDS differs from that in homosexuals. Neoplasms were found in 25 per cent of patients with sexual risks, but not in any drug abusers (0 per cent). Two opportunistic infections (toxoplasmosis and cytomegalovirus pneumonia and esophagitis) were more common in the intravenous drug abuser group. Although cytomegalovirus has been associated with Kaposi's sarcoma, this association was not found in this study. The postmortem findings in both groups were otherwise similar.

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The acquired immunodeficiency syndrome in intravenous drug abusers and patients with a sexual risk: Clinical and postmortem comparisons

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

UN SDGs

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