The adoption of alcohol pharmacotherapies in the Clinical Trials Network: The influence of research network participation

Amanda J. Abraham, Hannah K. Knudsen, Tanja C. Rothrauff, Paul M. Roman

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Organizational participation in clinical research may lead to adoption of the intervention by treatment agencies, but it is not known whether research involvement enhances innovativeness beyond the specific interventions that are tested. The National Institute on Drug Abuse's Clinical Trials Network (CTN) is a platform for considering this research question. To date, the CTN has not conducted research on medications for alcohol use disorders (AUDs), so greater adoption of innovative AUD pharmacotherapies by CTN-affiliated programs would suggest an added value of research network participation. Using longitudinal data from a pooled sample of CTN and non-CTN publicly funded treatment programs, we investigate adoption of tablet naltrexone and acamprosate over a 2-year period. CTN-affiliated programs were more likely to have adopted tablet naltrexone and acamprosate at 24-month follow-up, net of the effects of a range of organizational characteristics. Research network participation may thus enhance organizational innovativeness to include interventions beyond the scope of the network.

Original languageEnglish
Pages (from-to)275-283
Number of pages9
JournalJournal of Substance Abuse Treatment
Issue number3
StatePublished - Apr 2010

Bibliographical note

Funding Information:
The authors gratefully acknowledge the support from the NIDA (Grants R01DA13110 and R01DA14482 ) and from the National Institute on Alcohol Abuse and Alcoholism (Grants F32AA016872 and R01AA15974 ). The opinions expressed here are those of the authors and do not represent the official position of the National Institutes of Health.


  • Acamprosate
  • Adoption of innovations
  • Clinical Trials Network
  • Research networks
  • Tablet naltrexone

ASJC Scopus subject areas

  • Psychiatric Mental Health
  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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