The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction

Robin K. Minor, Miguel López, Caitlin M. Younts, Bruce Jones, Kevin J. Pearson, Robert Michael Anson, Carlos Diéguez, Rafael de Cabo

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Calorie restriction (CR) is known to have profound effects on tumor incidence. A typical consequence of CR is hunger, and we hypothesized that the neuroendocrine response to CR might in part mediate CR's antitumor effects. We tested CR under appetite suppression using two models: neuropeptide Y (NPY) knockout mice and monosodium glutamate-injected mice. While CR was protective in control mice challenged with a two-stage skin carcinogenesis model, papilloma development was neither delayed nor reduced by CR in the monosodium glutamate-treated and NPY knockout mice. Adiponectin levels were also not increased by CR in the appetite-suppressed mice. We propose that some of CR's beneficial effects cannot be separated from those imposed on appetite, and that NPY neurons in the arcuate nucleus of the hypothalamus are involved in the translation of reduced intake to downstream physiological and functional benefits. No claim to original US government works.

Original languageEnglish
Pages (from-to)483-492
Number of pages10
JournalAging Cell
Volume10
Issue number3
DOIs
StatePublished - Jun 2011

Keywords

  • Calorie restriction
  • Hypothalamus
  • Monosodium glutamate
  • Neuroendocrine
  • Neuropeptide Y
  • Tumorigenesis

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Fingerprint

Dive into the research topics of 'The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction'. Together they form a unique fingerprint.

Cite this