The Association between Depressive Symptoms and N-Terminal Pro-B-Type Natriuretic Peptide with Functional Status in Patients with Heart Failure

Zyad T. Saleh, Jia Rong Wu, Ibrahim Salami, Khalil Yousef, Terry A. Lennie

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and depressive symptoms are each associated with functional status in patients with heart failure (HF), but their association together with functional status has not been examined. Objective: The aim of this study was to determine whether functional status scores differ as a function of depressive symptoms and NT-proBNP levels considered together. Methods: We studied 284 patients with HF who were divided into 4 groups based on the median split of NT-proBNP levels and cut point for depressive symptoms (Beck Depression Inventory ≥ 14): (1) low NT-proBNP of 562.5 pg/mL or less without depressive symptoms, (2) low NT-proBNP of 562.5 pg/mL or less with depressive symptoms, (3) high NT-proBNP of greater than 562.5 pg/mL without depressive symptoms, and (4) high NT-proBNP of greater than 562.5 pg/mL with depressive symptoms. The Duke Activity Status Index was used to assess functional status. Results: Nonlinear regression demonstrated that patients without depressive symptoms were more than twice as likely to have higher (better) functional status scores than patients with depressive symptoms regardless of NT-proBNP levels after controlling for age, gender, prescribed antidepressants, and body mass index. Functional status levels of patients with low NT-proBNP did not differ from those with high NT-proBNP in the presence of depressive symptoms. Conclusion: When examined together, depressive symptoms rather than NT-proBNP levels predicted functional status. Clinical Implications: Adequate treatment of depressive symptoms may lead to better functional status regardless of HF severity.

Original languageEnglish
Pages (from-to)378-383
Number of pages6
JournalJournal of Cardiovascular Nursing
Volume33
Issue number4
DOIs
StatePublished - Jul 1 2018

Bibliographical note

Publisher Copyright:
© 2018 Lippincott Williams and Wilkins. All rights reserved.

Keywords

  • N-terminal pro-B-type natriuretic peptide
  • depressive symptoms
  • functional status
  • heart failure

ASJC Scopus subject areas

  • General Medicine

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