The association between frontal-striatal connectivity and sensorimotor control in cocaine users

Colleen A. Hanlon, Michael J. Wesley, Jennifer R. Stapleton, Paul J. Laurienti, Linda J. Porrino

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Background: In addition to cognitive and emotional processing dysfunction, chronic cocaine users are also impaired at simple sensorimotor tasks. Many diseases characterized by compulsive movements, repetitive actions, impaired attention and planning are associated with dysfunction in frontal-striatal circuits. The aim of this study was to determine whether cocaine users had impaired frontal-striatal connectivity during a simple movement task and whether this was associated with sensorimotor impairment. Methods: Functional MRI data were collected from 14 non-treatment seeking cocaine users and 15 healthy controls as they performed a finger-tapping task. Functional coupling was quantified by correlating the timecourses of each pair of anatomically connected regions of interest. Behavioral performance was correlated with all functional coupling coefficients. Results: In controls there was a significant relationship between the primary motor cortex and the supplementary motor area (SMA), as well as the SMA and the dorsal striatum during ongoing movement. Cocaine users exhibited weaker fronto-striatal coupling than controls, while the cortical-cortical coupling was intact. Coupling strength between the SMA and the caudate was negatively correlated with reaction time in the users. Conclusions: The observation that cocaine users have impaired cortical-striatal connectivity during simple motor performance, suggests that these individuals may have a fundamental deficit in information processing that influences more complex cognitive processes.

Original languageEnglish
Pages (from-to)240-243
Number of pages4
JournalDrug and Alcohol Dependence
Issue number3
StatePublished - Jun 1 2011

Bibliographical note

Funding Information:
This work was supported by the National Institute on Drug Abuse Grants DA021456 (CAH), DA020074 (LJP), and DA06634 (LJP). The funding source had no further role in study design, collection, analysis, interpretation or in the decision to submit the paper for publication.


  • Addiction
  • Connectivity
  • Neural networks
  • Neuroimaging
  • Sensorimotor
  • Striatum

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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