The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxia

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2 Scopus citations

Abstract

Chronic kidney disease (CKD) is increasing worldwide and is associated with diabetic states (obesity, prediabetes and type-2 diabetes mellitus). The kidney is intrinsically susceptible to low oxygen (hypoxia) and renal hypoxia plays a vital role in the progression of CKD. Recent studies suggest an association between CKD and renal deposition of amyloid-forming amylin secreted from the pancreas. Renal accumulation of amyloid-forming amylin is associated with hypertension, mitochondrial dysfunction, increased production of reactive oxygen species (ROS) and activation of hypoxia signaling in the kidney. In this review we will discuss potential associations between renal amylin amyloid accumulation, hypertension, and mechanism of hypoxia-induced kidney dysfunction, including activation of hypoxia-inducible factors (HIFs) and mitochondrial dysfunction.

Original languageEnglish
Article number1104662
JournalFrontiers in Endocrinology
Volume14
DOIs
StatePublished - 2023

Bibliographical note

Publisher Copyright:
Copyright © 2023 Verma and Despa.

Keywords

  • amylin
  • hypoxia
  • kidney disease
  • mitochondria
  • reactive oxygen species

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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