The association between schizophrenia and smoking: Unexplained by either the illness or the prodromal period

Francisco J. Diaz, Diana M. Velásquez, Margaret T. Susce, Jose de Leon

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Age at onset of daily smoking (AODS) was compared in schizophrenia (N = 258), mood disorders (N = 166) and controls (N = 381) to replicate a different AODS in schizophrenia patients, and to confirm that this is not necessarily explained by the prodromal period. The cumulative hazard curves for schizophrenia, mood disorders and controls were significantly different (p < 0.001), even after controlling for gender and education (p < 0.001). After excluding the patients who started smoking within 5 years of starting psychiatric medication, the cumulative hazard curve for schizophrenia patients was significantly different from that for ever-smoker controls (p = 0.002), even after adjusting for gender and education (p = 0.03).

Original languageEnglish
Pages (from-to)214-219
Number of pages6
JournalSchizophrenia Research
Volume104
Issue number1-3
DOIs
StatePublished - Sep 2008

Bibliographical note

Funding Information:
No pharmaceutical organization had any role in the writing of this paper for publication. The original pharmacogenetic study at the University of Kentucky Mental Health Research Center was supported by several sources: a researcher-initiated grant from Roche Molecular Systems, Inc., a NARSAD Independent Investigator Award to Jose de Leon, M.D, and internal resources. Statistical analyses were conducted without additional external support.

Keywords

  • Mood disorders
  • Nicotine
  • Schizophrenia
  • Smoking
  • Survival analysis
  • Tobacco

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint

Dive into the research topics of 'The association between schizophrenia and smoking: Unexplained by either the illness or the prodromal period'. Together they form a unique fingerprint.

Cite this