The association between schizophrenia and smoking: Unexplained by either the illness or the prodromal period

Francisco J. Diaz; Diana M. Velásquez; Margaret T. Susce; Jose de Leon

doi:10.1016/j.schres.2008.06.004

The association between schizophrenia and smoking: Unexplained by either the illness or the prodromal period

Francisco J. Diaz, Diana M. Velásquez, Margaret T. Susce, Jose de Leon

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Age at onset of daily smoking (AODS) was compared in schizophrenia (N = 258), mood disorders (N = 166) and controls (N = 381) to replicate a different AODS in schizophrenia patients, and to confirm that this is not necessarily explained by the prodromal period. The cumulative hazard curves for schizophrenia, mood disorders and controls were significantly different (p < 0.001), even after controlling for gender and education (p < 0.001). After excluding the patients who started smoking within 5 years of starting psychiatric medication, the cumulative hazard curve for schizophrenia patients was significantly different from that for ever-smoker controls (p = 0.002), even after adjusting for gender and education (p = 0.03).

Original language	English
Pages (from-to)	214-219
Number of pages	6
Journal	Schizophrenia Research
Volume	104
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2008.06.004
State	Published - Sep 2008

Bibliographical note

Funding Information:
No pharmaceutical organization had any role in the writing of this paper for publication. The original pharmacogenetic study at the University of Kentucky Mental Health Research Center was supported by several sources: a researcher-initiated grant from Roche Molecular Systems, Inc., a NARSAD Independent Investigator Award to Jose de Leon, M.D, and internal resources. Statistical analyses were conducted without additional external support.

Keywords

Mood disorders
Nicotine
Schizophrenia
Smoking
Survival analysis
Tobacco

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2008.06.004

Cite this

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title = "The association between schizophrenia and smoking: Unexplained by either the illness or the prodromal period",

abstract = "Age at onset of daily smoking (AODS) was compared in schizophrenia (N = 258), mood disorders (N = 166) and controls (N = 381) to replicate a different AODS in schizophrenia patients, and to confirm that this is not necessarily explained by the prodromal period. The cumulative hazard curves for schizophrenia, mood disorders and controls were significantly different (p < 0.001), even after controlling for gender and education (p < 0.001). After excluding the patients who started smoking within 5 years of starting psychiatric medication, the cumulative hazard curve for schizophrenia patients was significantly different from that for ever-smoker controls (p = 0.002), even after adjusting for gender and education (p = 0.03).",

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note = "Funding Information: No pharmaceutical organization had any role in the writing of this paper for publication. The original pharmacogenetic study at the University of Kentucky Mental Health Research Center was supported by several sources: a researcher-initiated grant from Roche Molecular Systems, Inc., a NARSAD Independent Investigator Award to Jose de Leon, M.D, and internal resources. Statistical analyses were conducted without additional external support. ",

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AU - Susce, Margaret T.

AU - de Leon, Jose

N1 - Funding Information: No pharmaceutical organization had any role in the writing of this paper for publication. The original pharmacogenetic study at the University of Kentucky Mental Health Research Center was supported by several sources: a researcher-initiated grant from Roche Molecular Systems, Inc., a NARSAD Independent Investigator Award to Jose de Leon, M.D, and internal resources. Statistical analyses were conducted without additional external support.

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KW - Survival analysis

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The association between schizophrenia and smoking: Unexplained by either the illness or the prodromal period

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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