Purpose: The purpose of this study was to determine whether deficiencies of water-soluble vitamin intake predicted health-related quality of life (HRQOL) and the composite end point of all-cause mortality or cardiac- or heart failure (HF)-related hospitalization in HF patients. Patients with HF may be at risk for inadequate consumption of water-soluble vitamins due to poor appetite and dietary sodium restriction. Because water-soluble vitamins are important in metabolic processes, inadequate dietary intake of these vitamins may negatively affect health outcomes. Methods: We consecutively recruited patients with HF from outpatient clinics affiliated with academic medical centers. Patients were referred by providers to investigators who verified their eligibility. Patients with HF completed a four-day food diary to determine dietary deficiencies of water-soluble vitamins and the Minnesota Living with HF questionnaire to assess HRQOL at baseline. Patients were followed to determine an event. Results: A total of 216 patients were included. Patients with a higher number of dietary deficiencies of water-soluble vitamins had poorer HRQOL (unstandardized coefficient = 4.92, 95% confidence interval 2.20–7.27). Cox regression showed that for each additional deficiency of a water-soluble vitamin intake, there was a 30% increase in risk for an event (95% confidence interval 1.03–1.75), controlling for demographic and clinical variables. Conclusion: Inadequate dietary consumption of water-soluble vitamins was associated with poor HRQOL and prognosis and in HF. Our findings highlight that clinicians should understand the importance of encouraging patients to consume water-soluble vitamin-rich foods, which may result in enhancing outcomes in HF.
|Number of pages||8|
|Journal||Quality of Life Research|
|State||Published - Apr 2021|
Bibliographical noteFunding Information:
The National Institute of Nursing Research and a Center grant from NIH National Institute of Nursing Research # 1P20NR010679 and the National Research Foundation of Korea grant funded by the Korea Government (MEST) (2016R1A2B4008495).
© 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature.
- Health-related quality of life
- Heart failure
- Water-soluble vitamins
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health