Abstract
The serine/threonine-specific protein kinase AKT is gaining recognition as a major crossroad in numerous cellular signaling pathways through its ability to regulate cell differentiation, proliferation, survival and metabolism. This review focuses on the recent advances in AKT signaling and downstream events in T cells, emphasizing its contrasting role in conventional and regulatory (Treg) Tcell populations. Activation of AKT has been known for many years to be critical in the development and function of conventional Tcells. However, it has just recently been uncovered that AKTexerts an inhibitory effect on Treg generation and suppressor function. These studies have placed AKTat the nexus of Treg development and function, thus opening novel avenues for therapeutic manipulation.
| Original language | English |
|---|---|
| Pages (from-to) | 160-174 |
| Number of pages | 15 |
| Journal | Frontiers in Biology |
| Volume | 8 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2013 |
Bibliographical note
Funding Information:We thank M. Moliner for assistance with graphics. This work was partially supported by NIH Grant Numbers R03AR052904-02 from the NIAMS and 2P20 RR020171 from the NCRR to F.M. The authors declare no financial or commercial conflict of interest.
Funding
We thank M. Moliner for assistance with graphics. This work was partially supported by NIH Grant Numbers R03AR052904-02 from the NIAMS and 2P20 RR020171 from the NCRR to F.M. The authors declare no financial or commercial conflict of interest.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | R03AR052904-02 |
| National Institute of Arthritis and Musculoskeletal and Skin Diseases | 2P20 RR020171 |
| National Center for Research Resources |
Keywords
- AKT
- T cell differentiation
- T cell signaling
- Tregs
ASJC Scopus subject areas
- Biotechnology
- Ecology, Evolution, Behavior and Systematics
- Ecology
- Genetics