The Beclin 1-VPS34 complex - at the crossroads of autophagy and beyond

Sarah F. Funderburk; Qing Jun Wang; Zhenyu Yue

doi:10.1016/j.tcb.2010.03.002

The Beclin 1-VPS34 complex - at the crossroads of autophagy and beyond

Sarah F. Funderburk, Qing Jun Wang, Zhenyu Yue

Opthalmology

Research output: Contribution to journal › Review article › peer-review

677 Scopus citations

Abstract

An increasing body of research on autophagy provides overwhelming evidence for its connection to diverse biological functions and human diseases. Beclin 1, the first mammalian autophagy protein to be described, appears to act as a nexus point between autophagy, endosomal, and perhaps also cell death pathways. Beclin 1 performs these roles as part of a core complex that contains vacuolar sorting protein 34 (VPS34), a class III phosphatidylinositol-3 kinase. The precise mechanism of Beclin 1-mediated regulation of these cellular functions is unclear, but substantial progress has recently been made in identifying new players and their functions in Beclin 1-VSP34 complexes. Here we review emerging studies that are beginning to unveil the physiological functions of Beclin 1-VPS34 in the central control of autophagic activity and other trafficking events through the formation of distinct Beclin 1-VPS34 protein complexes.

Original language	English
Pages (from-to)	355-362
Number of pages	8
Journal	Trends in Cell Biology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/j.tcb.2010.03.002
State	Published - Jun 2010

Bibliographical note

Funding Information:
We thank members of Yue laboratory and Dr. Qing Zhong for critical reading. This work was supported by NIH grant RO1NS060123 (Z.Y.), Michael J. Fox Foundation for Parkinson's Research (Z.Y.) and NIH COBRE 2P20RR020171 (Q.J.W.). We apologize to colleagues whose publications could not be cited owing to space limit.

ASJC Scopus subject areas

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tcb.2010.03.002

Cite this

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title = "The Beclin 1-VPS34 complex - at the crossroads of autophagy and beyond",

abstract = "An increasing body of research on autophagy provides overwhelming evidence for its connection to diverse biological functions and human diseases. Beclin 1, the first mammalian autophagy protein to be described, appears to act as a nexus point between autophagy, endosomal, and perhaps also cell death pathways. Beclin 1 performs these roles as part of a core complex that contains vacuolar sorting protein 34 (VPS34), a class III phosphatidylinositol-3 kinase. The precise mechanism of Beclin 1-mediated regulation of these cellular functions is unclear, but substantial progress has recently been made in identifying new players and their functions in Beclin 1-VSP34 complexes. Here we review emerging studies that are beginning to unveil the physiological functions of Beclin 1-VPS34 in the central control of autophagic activity and other trafficking events through the formation of distinct Beclin 1-VPS34 protein complexes.",

author = "Funderburk, {Sarah F.} and Wang, {Qing Jun} and Zhenyu Yue",

note = "Funding Information: We thank members of Yue laboratory and Dr. Qing Zhong for critical reading. This work was supported by NIH grant RO1NS060123 (Z.Y.), Michael J. Fox Foundation for Parkinson's Research (Z.Y.) and NIH COBRE 2P20RR020171 (Q.J.W.). We apologize to colleagues whose publications could not be cited owing to space limit.",

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AU - Yue, Zhenyu

N1 - Funding Information: We thank members of Yue laboratory and Dr. Qing Zhong for critical reading. This work was supported by NIH grant RO1NS060123 (Z.Y.), Michael J. Fox Foundation for Parkinson's Research (Z.Y.) and NIH COBRE 2P20RR020171 (Q.J.W.). We apologize to colleagues whose publications could not be cited owing to space limit.

PY - 2010/6

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N2 - An increasing body of research on autophagy provides overwhelming evidence for its connection to diverse biological functions and human diseases. Beclin 1, the first mammalian autophagy protein to be described, appears to act as a nexus point between autophagy, endosomal, and perhaps also cell death pathways. Beclin 1 performs these roles as part of a core complex that contains vacuolar sorting protein 34 (VPS34), a class III phosphatidylinositol-3 kinase. The precise mechanism of Beclin 1-mediated regulation of these cellular functions is unclear, but substantial progress has recently been made in identifying new players and their functions in Beclin 1-VSP34 complexes. Here we review emerging studies that are beginning to unveil the physiological functions of Beclin 1-VPS34 in the central control of autophagic activity and other trafficking events through the formation of distinct Beclin 1-VPS34 protein complexes.

AB - An increasing body of research on autophagy provides overwhelming evidence for its connection to diverse biological functions and human diseases. Beclin 1, the first mammalian autophagy protein to be described, appears to act as a nexus point between autophagy, endosomal, and perhaps also cell death pathways. Beclin 1 performs these roles as part of a core complex that contains vacuolar sorting protein 34 (VPS34), a class III phosphatidylinositol-3 kinase. The precise mechanism of Beclin 1-mediated regulation of these cellular functions is unclear, but substantial progress has recently been made in identifying new players and their functions in Beclin 1-VSP34 complexes. Here we review emerging studies that are beginning to unveil the physiological functions of Beclin 1-VPS34 in the central control of autophagic activity and other trafficking events through the formation of distinct Beclin 1-VPS34 protein complexes.

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JO - Trends in Cell Biology

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The Beclin 1-VPS34 complex - at the crossroads of autophagy and beyond

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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