The Bergman cycloaromatization reaction efficiently converts easily prepared acyclic enediynes into aromatic rings. In order to prepare larger, functionalized fused aromatic systems using this reaction, a thorough understanding of how functionalization affects cycloaromatization is necessary. We present here our studies on the influence of substituents at three different functionalization sites on cycloaromatization, and how these functional groups can be tailored to prepare more complex systems.
|Number of pages||8|
|State||Published - Apr 23 2001|
Bibliographical noteFunding Information:
This work was supported by the National Science Foundation (CAREER Award CHE 9875123), the Office of Naval Research and the University of Kentucky Research Foundation. NMR Facilities used in this research were enhanced by funds from the CRIF program of the National Science Foundation (CHE 997841) and from the Research Challenge Trust Fund of the University of Kentucky.
- Bergman reaction
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry