TY - JOUR
T1 - The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase
AU - Funabashi, Masanori
AU - Baba, Satoshi
AU - Nonaka, Koichi
AU - Hosobuchi, Masahiko
AU - Fujita, Yoko
AU - Shibata, Tomoyuki
AU - Van Lanen, Steven G.
PY - 2010/1/25
Y1 - 2010/1/25
N2 - Lip reading: The biosynthetic gene cluster for A-90289, a fatty acid nucleoside antibiotic, was cloned and sequenced. The sulfotransferase LipB is demonstrated to be essential for A-90289 biosynthesis, and in vitro characterization revealed LipB utilizes p-nitrophenylsulfate as an aryl sulfate donor and a variety of nonaryl acceptors including caprazamycin A to give the 2′-O-sulfated product, A-90289A. (Chemical Equation Presented).
AB - Lip reading: The biosynthetic gene cluster for A-90289, a fatty acid nucleoside antibiotic, was cloned and sequenced. The sulfotransferase LipB is demonstrated to be essential for A-90289 biosynthesis, and in vitro characterization revealed LipB utilizes p-nitrophenylsulfate as an aryl sulfate donor and a variety of nonaryl acceptors including caprazamycin A to give the 2′-O-sulfated product, A-90289A. (Chemical Equation Presented).
KW - Antibiotics
KW - Bacterial translocase I
KW - Biosynthesis
KW - Nucleosides
KW - Sulfotransferase
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U2 - 10.1002/cbic.200900665
DO - 10.1002/cbic.200900665
M3 - Article
C2 - 20043306
AN - SCOPUS:76649083231
SN - 1439-4227
VL - 11
SP - 184
EP - 190
JO - ChemBioChem
JF - ChemBioChem
IS - 2
ER -