The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase

Masanori Funabashi; Satoshi Baba; Koichi Nonaka; Masahiko Hosobuchi; Yoko Fujita; Tomoyuki Shibata; Steven G. Van Lanen

doi:10.1002/cbic.200900665

The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase

Masanori Funabashi
, Satoshi Baba
, Koichi Nonaka
, Masahiko Hosobuchi
, Yoko Fujita
, Tomoyuki Shibata
, Steven G. Van Lanen

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Lip reading: The biosynthetic gene cluster for A-90289, a fatty acid nucleoside antibiotic, was cloned and sequenced. The sulfotransferase LipB is demonstrated to be essential for A-90289 biosynthesis, and in vitro characterization revealed LipB utilizes p-nitrophenylsulfate as an aryl sulfate donor and a variety of nonaryl acceptors including caprazamycin A to give the 2′-O-sulfated product, A-90289A. (Chemical Equation Presented).

Original language	English
Pages (from-to)	184-190
Number of pages	7
Journal	ChemBioChem
Volume	11
Issue number	2
DOIs	https://doi.org/10.1002/cbic.200900665
State	Published - Jan 25 2010

Keywords

Antibiotics
Bacterial translocase I
Biosynthesis
Nucleosides
Sulfotransferase

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

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10.1002/cbic.200900665

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abstract = "Lip reading: The biosynthetic gene cluster for A-90289, a fatty acid nucleoside antibiotic, was cloned and sequenced. The sulfotransferase LipB is demonstrated to be essential for A-90289 biosynthesis, and in vitro characterization revealed LipB utilizes p-nitrophenylsulfate as an aryl sulfate donor and a variety of nonaryl acceptors including caprazamycin A to give the 2′-O-sulfated product, A-90289A. (Chemical Equation Presented).",

keywords = "Antibiotics, Bacterial translocase I, Biosynthesis, Nucleosides, Sulfotransferase",

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AU - Funabashi, Masanori

AU - Baba, Satoshi

AU - Nonaka, Koichi

AU - Hosobuchi, Masahiko

AU - Fujita, Yoko

AU - Shibata, Tomoyuki

AU - Van Lanen, Steven G.

PY - 2010/1/25

Y1 - 2010/1/25

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AB - Lip reading: The biosynthetic gene cluster for A-90289, a fatty acid nucleoside antibiotic, was cloned and sequenced. The sulfotransferase LipB is demonstrated to be essential for A-90289 biosynthesis, and in vitro characterization revealed LipB utilizes p-nitrophenylsulfate as an aryl sulfate donor and a variety of nonaryl acceptors including caprazamycin A to give the 2′-O-sulfated product, A-90289A. (Chemical Equation Presented).

KW - Antibiotics

KW - Bacterial translocase I

KW - Biosynthesis

KW - Nucleosides

KW - Sulfotransferase

UR - https://www.scopus.com/pages/publications/76649083231

UR - https://www.scopus.com/pages/publications/76649083231#tab=citedBy

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The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase

Abstract

Keywords

ASJC Scopus subject areas

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