@article{d9f6034727244cd0b35cdb0b6a6c2480,
title = "The Cav 1.2 Ca2+ channel is expressed in sarcolemma of type I and IIA myofibers of adult skeletal muscle",
abstract = "Although Ca2+-dependent signaling pathways are important for skeletal muscle plasticity, the sources of Ca2+ that activate these signaling pathways are not completely understood. Influx of Ca2+ through surface membrane Ca2+ channels may activate these pathways. We examined expression of two L-type Ca2+ channels in adult skeletal muscle, the CaV 1.1 and CaV 1.2, with isoform-specific antibodies in Western blots and immunocytochemistry assays. Consistent with a large body of work, expression of the CaV 1.1 was restricted to skeletal muscle where it was expressed in T-tubules. CaV 1.2 was also expressed in skeletal muscle, in the sarcolemma of type I and IIa myofibers. Exercise-induced alterations in muscle fiber types cause a concomitant increase in the number of both CaV 1.2 and type IIa-positive fibers. Taken together, these data suggest that the CaV 1.2 Ca2+ channel is expressed in adult skeletal muscle in a fiber type-specific manner, which may help to maintain oxidative muscle phenotype.",
keywords = "Calcineurin, Exercise, Fiber type specificity, L-type voltage-gated calcium channel, Muscle plasticity",
author = "Jeftinija, {Du{\v s}an M.} and Qing, {Bo Wang} and Hebert, {Sadie L.} and Norris, {Christopher M.} and Zhen Yan and Rich, {Mark M.} and Kraner, {Susan D.}",
year = "2007",
month = oct,
doi = "10.1002/mus.20842",
language = "English",
volume = "36",
pages = "482--490",
number = "4",
}