TY - JOUR
T1 - The Cdc28 inhibitor p40SIC1.
AU - Mendenhall, M. D.
AU - al-Jumaily, W.
AU - Nugroho, T. T.
PY - 1995
Y1 - 1995
N2 - Sic1 inhibits the activity of Cdc28.Clb5 complexes in late G1, creating a delay between cell cycle commitment and S phase initiation. The ultimate purpose of this delay is unknown but loss of Sic1 activity negatively affects genomic stability and cellular viability. Sic1 levels are controlled by periodic changes in transcription rates and protein stability. The latter control is mediated through the Cdc34 ubiquitin transferase and, possibly, Cdc28.Cln activity. Possible roles of Sic1 in the G1/S and the M/G1 transitions are discussed.
AB - Sic1 inhibits the activity of Cdc28.Clb5 complexes in late G1, creating a delay between cell cycle commitment and S phase initiation. The ultimate purpose of this delay is unknown but loss of Sic1 activity negatively affects genomic stability and cellular viability. Sic1 levels are controlled by periodic changes in transcription rates and protein stability. The latter control is mediated through the Cdc34 ubiquitin transferase and, possibly, Cdc28.Cln activity. Possible roles of Sic1 in the G1/S and the M/G1 transitions are discussed.
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U2 - 10.1007/978-1-4615-1809-9_14
DO - 10.1007/978-1-4615-1809-9_14
M3 - Review article
C2 - 9552362
AN - SCOPUS:0029418178
SN - 1087-2957
VL - 1
SP - 173
EP - 185
JO - Progress in cell cycle research
JF - Progress in cell cycle research
ER -