The Cdc28 inhibitor p40SIC1.

M. D. Mendenhall; W. al-Jumaily; T. T. Nugroho

doi:10.1007/978-1-4615-1809-9_14

The Cdc28 inhibitor p40SIC1.

M. D. Mendenhall
, W. al-Jumaily
, T. T. Nugroho

Molecular and Cellular Biochemistry

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Sic1 inhibits the activity of Cdc28.Clb5 complexes in late G1, creating a delay between cell cycle commitment and S phase initiation. The ultimate purpose of this delay is unknown but loss of Sic1 activity negatively affects genomic stability and cellular viability. Sic1 levels are controlled by periodic changes in transcription rates and protein stability. The latter control is mediated through the Cdc34 ubiquitin transferase and, possibly, Cdc28.Cln activity. Possible roles of Sic1 in the G1/S and the M/G1 transitions are discussed.

Original language	English
Pages (from-to)	173-185
Number of pages	13
Journal	Progress in cell cycle research
Volume	1
DOIs	https://doi.org/10.1007/978-1-4615-1809-9_14
State	Published - 1995

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4615-1809-9_14

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title = "The Cdc28 inhibitor p40SIC1.",

abstract = "Sic1 inhibits the activity of Cdc28.Clb5 complexes in late G1, creating a delay between cell cycle commitment and S phase initiation. The ultimate purpose of this delay is unknown but loss of Sic1 activity negatively affects genomic stability and cellular viability. Sic1 levels are controlled by periodic changes in transcription rates and protein stability. The latter control is mediated through the Cdc34 ubiquitin transferase and, possibly, Cdc28.Cln activity. Possible roles of Sic1 in the G1/S and the M/G1 transitions are discussed.",

author = "Mendenhall, \{M. D.\} and W. al-Jumaily and Nugroho, \{T. T.\}",

year = "1995",

doi = "10.1007/978-1-4615-1809-9\_14",

language = "English",

volume = "1",

pages = "173--185",

}

TY - JOUR

T1 - The Cdc28 inhibitor p40SIC1.

AU - Mendenhall, M. D.

AU - al-Jumaily, W.

AU - Nugroho, T. T.

PY - 1995

Y1 - 1995

N2 - Sic1 inhibits the activity of Cdc28.Clb5 complexes in late G1, creating a delay between cell cycle commitment and S phase initiation. The ultimate purpose of this delay is unknown but loss of Sic1 activity negatively affects genomic stability and cellular viability. Sic1 levels are controlled by periodic changes in transcription rates and protein stability. The latter control is mediated through the Cdc34 ubiquitin transferase and, possibly, Cdc28.Cln activity. Possible roles of Sic1 in the G1/S and the M/G1 transitions are discussed.

AB - Sic1 inhibits the activity of Cdc28.Clb5 complexes in late G1, creating a delay between cell cycle commitment and S phase initiation. The ultimate purpose of this delay is unknown but loss of Sic1 activity negatively affects genomic stability and cellular viability. Sic1 levels are controlled by periodic changes in transcription rates and protein stability. The latter control is mediated through the Cdc34 ubiquitin transferase and, possibly, Cdc28.Cln activity. Possible roles of Sic1 in the G1/S and the M/G1 transitions are discussed.

UR - https://www.scopus.com/pages/publications/0029418178

UR - https://www.scopus.com/pages/publications/0029418178#tab=citedBy

U2 - 10.1007/978-1-4615-1809-9_14

DO - 10.1007/978-1-4615-1809-9_14

M3 - Review article

C2 - 9552362

AN - SCOPUS:0029418178

SN - 1087-2957

VL - 1

SP - 173

EP - 185

JO - Progress in cell cycle research

JF - Progress in cell cycle research

ER -

The Cdc28 inhibitor p40SIC1.

Abstract

ASJC Scopus subject areas

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