The cerebral proteopathies: Neurodegenerative disorders of protein conformation and assembly

L. C. Walker, H. LeVine

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


The abnormal assembly and deposition of specific proteins in the brain is the probable cause of most neurodegenerative disease afflicting the elderly. These "cerebral proteopathies" include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), prion diseases, and a variety of other disorders. Evidence is accumulating that the anomalous aggregation of the proteins, and not a loss of protein function, is central to the pathogenesis of these diseases. Thus, therapeutic strategies that reduce the production, accumulation, or polymerization of pathogenic proteins might be applicable to a wide range of some of the most devastating diseases of old age.

Original languageEnglish
Pages (from-to)83-95
Number of pages13
JournalMolecular Neurobiology
Issue number1-2
StatePublished - 2000


  • Aging
  • Alzheimer's disease
  • Amyloid
  • Amyotrophic lateral sclerosis
  • Dementia
  • Diabetes
  • Huntington's disease
  • Parkinson's disease
  • Prion
  • Proteopathy

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience


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