TY - CHAP
T1 - The challenges of respiratory motor system recovery following cervical spinal cord injury
AU - Warren, Philippa M.
AU - Alilain, Warren J.
PY - 2014
Y1 - 2014
N2 - High cervical spinal cord injury (SCI) typically results in partial paralysis of the diaphragm due to intrusion of descending inspiratory drive at the level of the phrenic nucleus. The degree to which such paralysis occurs depends on the type, force, level, and extent of trauma produced. While endogenous recovery and plasticity may occur, the resulting respiratory complications can lead to morbidity and death. However, it has been shown that through modification of intrinsic motor neuron properties, or altering the environment localized at the site of SCI, functional recovery and plasticity of the respiratory motor system can be facilitated. The present review emphasizes these factors and correlates it to the treatment of SCI at the level of the somatic nervous system. Despite these promising therapies, functional respiratory motor system recovery following cervical SCI is often minimal. This review thus focuses on possible directions for the field, with emphasis on combinatorial treatment.
AB - High cervical spinal cord injury (SCI) typically results in partial paralysis of the diaphragm due to intrusion of descending inspiratory drive at the level of the phrenic nucleus. The degree to which such paralysis occurs depends on the type, force, level, and extent of trauma produced. While endogenous recovery and plasticity may occur, the resulting respiratory complications can lead to morbidity and death. However, it has been shown that through modification of intrinsic motor neuron properties, or altering the environment localized at the site of SCI, functional recovery and plasticity of the respiratory motor system can be facilitated. The present review emphasizes these factors and correlates it to the treatment of SCI at the level of the somatic nervous system. Despite these promising therapies, functional respiratory motor system recovery following cervical SCI is often minimal. This review thus focuses on possible directions for the field, with emphasis on combinatorial treatment.
KW - Channelrhodopsin-2
KW - Chondroitinase
KW - Respiratory motor system
KW - Spinal cord injury
UR - http://www.scopus.com/inward/record.url?scp=84918522890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84918522890&partnerID=8YFLogxK
U2 - 10.1016/B978-0-444-63488-7.00010-0
DO - 10.1016/B978-0-444-63488-7.00010-0
M3 - Chapter
C2 - 25194199
AN - SCOPUS:84918522890
T3 - Progress in Brain Research
SP - 173
EP - 220
BT - Progress in Brain Research
ER -