The challenges of respiratory motor system recovery following cervical spinal cord injury

Philippa M. Warren; Warren J. Alilain

doi:10.1016/B978-0-444-63488-7.00010-0

The challenges of respiratory motor system recovery following cervical spinal cord injury

Philippa M. Warren, Warren J. Alilain

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

21 Scopus citations

Abstract

High cervical spinal cord injury (SCI) typically results in partial paralysis of the diaphragm due to intrusion of descending inspiratory drive at the level of the phrenic nucleus. The degree to which such paralysis occurs depends on the type, force, level, and extent of trauma produced. While endogenous recovery and plasticity may occur, the resulting respiratory complications can lead to morbidity and death. However, it has been shown that through modification of intrinsic motor neuron properties, or altering the environment localized at the site of SCI, functional recovery and plasticity of the respiratory motor system can be facilitated. The present review emphasizes these factors and correlates it to the treatment of SCI at the level of the somatic nervous system. Despite these promising therapies, functional respiratory motor system recovery following cervical SCI is often minimal. This review thus focuses on possible directions for the field, with emphasis on combinatorial treatment.

Original language	English
Title of host publication	Progress in Brain Research
Pages	173-220
Number of pages	48
Edition	C
DOIs	https://doi.org/10.1016/B978-0-444-63488-7.00010-0
State	Published - 2014

Publication series

Name	Progress in Brain Research
Number	C
Volume	212
ISSN (Print)	0079-6123
ISSN (Electronic)	1875-7855

Bibliographical note

Publisher Copyright:
© 2014 Elsevier B.V.

Funding

This work was supported by funding to W. J. A. from the International Spinal Research Trust in the UK, the Craig H. Neilsen Foundation, and the MetroHealth Medical Center in Cleveland, Ohio, USA. We thank Drs. B. Awad, D. Gutierrez, and K. Hoy for their constructive comments. The authors also acknowledge Drs. Gert Holstege, Mathias Dutschmann, and Hari Subramanian, the organizers of the XIIth Oxford Conference on “Breathing, Emotion, and Evolution,” and Dr. Gordon Mitchell, the Chair of the Spinal Cord Mechanisms session, for their kind invitation and oversight.

Funders	Funder number
MetroHealth Medical Center Cleveland
Craig H. Neilsen Foundation

Keywords

Channelrhodopsin-2
Chondroitinase
Respiratory motor system
Spinal cord injury

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/B978-0-444-63488-7.00010-0

Cite this

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The challenges of respiratory motor system recovery following cervical spinal cord injury

Abstract

Publication series

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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