Abstract
Although silicosis has been studied extensively, the mechanism is still not fully under-stood. Experiments do provide evidence that the actions of unique properties of silica surface on the cell membrane are the starting point of silicotic processes. This paper summarizes literature on chemical properties of silica surface, and the effect of particle size on silica toxicity. This paper also discusses the ways in which silica dusts are thought to interact with the cell membrane, with emphasis on freshness, hydrogen bonding, and free-radical interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 435-454 |
| Number of pages | 20 |
| Journal | Journal of Toxicology and Environmental Health |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1 1989 |
Bibliographical note
Funding Information:This work has been supported in part by the Department of the Interior's Mineral Institute program administered through the Generic Mineral Technology Center for Respirable Dust Center under grant G1134142.
Funding
This work has been supported in part by the Department of the Interior's Mineral Institute program administered through the Generic Mineral Technology Center for Respirable Dust Center under grant G1134142.
| Funders | Funder number |
|---|---|
| Department of the Interior's Mineral Institute | |
| Generic Mineral Technology Center for Respirable Dust | G1134142 |
ASJC Scopus subject areas
- Toxicology
- Pollution