The chemokine system: A possible therapeutic target in acute graft versus host disease

Nicolai A. Kittan, Gerhard C. Hildebrandt

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Allogeneic hematopoetic stem cell transplantation often presents the only chance for cure in a number of malignant and nonmalignant hematologic diseases. However, its beneficial effects are counterweighed by the development of potentially lethal complications, most importantly the development of acute and chronic graft-vs.-host disease (GVHD). Alloantigen-reactive immune responses mediate injury and destruction of GVHD target organs, including the gastrointestinal tract, the liver, the skin, and the lung. Donor leukocyte infiltration into the respective tissues is orchestrated by interactions between chemokines and chemokine receptors, which will be reviewed using a basic science - clinical comparative approach.

Original languageEnglish
Pages (from-to)97-120
Number of pages24
JournalCurrent Topics in Microbiology and Immunology
Volume341
Issue number1
DOIs
StatePublished - 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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