The cisterna magna in second-trimester fetuses with abnormal karyotypes

William J. Watson, Vern L. Katz, Nancy C. Chescheir, Richard C. Miller, M. Kathryn Menard, Wendy F. Hansen

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Six hundred thirty-eight gravidas at 14–21 weeks' gestation, who were at increased risk for an abnormal fetal karyotype, had sonographic measurement of the fetal cisterna magna at the level of the posterior fossa before genetic amniocentesis. The size of the fetal cisterna magna increased significantly with advancing gestational age in the normal fetus (P < .001). Twenty-eight fetuses had abnormal karyotypes: 12 with trisomy, eight with translocation or structural rearrangements, seven with sex chromosome abnormalities, and one with triploidy. In each of these fetuses with abnormal karyotypes, the cisterna magna measurement was normal. We conclude that measurement of the fetal cisterna magna at 14–21 weeks' gestation is not useful as a screening test for abnormal fetal karyotype.

Original languageEnglish
Pages (from-to)723-725
Number of pages3
JournalObstetrics and Gynecology
Volume79
Issue number5
StatePublished - May 1992

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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