The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancers

Damian Jacenik, Pawel Hikisz, Ellen J. Beswick, Jakub Fichna

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Among the numerous adhesion G protein-coupled receptors (GPCRs), adhesion G protein-coupled estrogen receptor F5 (ADGRF5) contains unique domains in the long N-terminal tail which can determine cell-cell and cell-matrix interaction as well as cell adhesion. Nevertheless, the biology of ADGRF5 is complex and still poorly explored. Accumulating evidence suggests that the ADGRF5 activity is fundamental in health and disease. For instance, ADGRF5 is essential in the proper function of lungs and kidney as well as the endocrine system, and its signification in vascularization and tumorigenesis has been demonstrated. The most recent studies have provided findings about the diagnostic potential of ADGRF5 in osteoporosis and cancers, and ongoing studies suggest other diseases as well. Here, we elaborate on the current state of knowledge about the ADGRF5 in the physiology and pathophysiology of human diseases and highlight its high potential as a novel target in various therapeutic areas.

Original languageEnglish
Article number166683
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Issue number5
StatePublished - Jun 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors


  • ADGRF5
  • Adhesion G protein-coupled receptor
  • Adhesion G protein-coupled receptor F5
  • G protein-coupled receptor 116
  • GPR116
  • Ig-Hepta

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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