Among the numerous adhesion G protein-coupled receptors (GPCRs), adhesion G protein-coupled estrogen receptor F5 (ADGRF5) contains unique domains in the long N-terminal tail which can determine cell-cell and cell-matrix interaction as well as cell adhesion. Nevertheless, the biology of ADGRF5 is complex and still poorly explored. Accumulating evidence suggests that the ADGRF5 activity is fundamental in health and disease. For instance, ADGRF5 is essential in the proper function of lungs and kidney as well as the endocrine system, and its signification in vascularization and tumorigenesis has been demonstrated. The most recent studies have provided findings about the diagnostic potential of ADGRF5 in osteoporosis and cancers, and ongoing studies suggest other diseases as well. Here, we elaborate on the current state of knowledge about the ADGRF5 in the physiology and pathophysiology of human diseases and highlight its high potential as a novel target in various therapeutic areas.
|Journal||Biochimica et Biophysica Acta - Molecular Basis of Disease|
|State||Published - Jun 2023|
Bibliographical noteFunding Information:
This work was supported by a grants ( 2019/32/C/NZ5/00064 to DJ) from the National Science Centre, Poland ; ( 6/IDUB/MLOD/2021 to DJ) from the University of Lodz, Poland; ( R01CA207051 to EJB) from the National Cancer Institute , USA and statutory funds of the Department of Biochemistry, Faculty of Medicine, Medical University of Lodz , Poland ( 503/1-156-04/503-11-001-19 to JF).
DJ was supported by the Foundation for Polish Science (FNP, START 30.2021 ).
© 2023 The Authors
- Adhesion G protein-coupled receptor
- Adhesion G protein-coupled receptor F5
- G protein-coupled receptor 116
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology