The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancers

Damian Jacenik; Pawel Hikisz; Ellen J. Beswick; Jakub Fichna

doi:10.1016/j.bbadis.2023.166683

The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancers

Damian Jacenik, Pawel Hikisz, Ellen J. Beswick, Jakub Fichna

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Among the numerous adhesion G protein-coupled receptors (GPCRs), adhesion G protein-coupled estrogen receptor F5 (ADGRF5) contains unique domains in the long N-terminal tail which can determine cell-cell and cell-matrix interaction as well as cell adhesion. Nevertheless, the biology of ADGRF5 is complex and still poorly explored. Accumulating evidence suggests that the ADGRF5 activity is fundamental in health and disease. For instance, ADGRF5 is essential in the proper function of lungs and kidney as well as the endocrine system, and its signification in vascularization and tumorigenesis has been demonstrated. The most recent studies have provided findings about the diagnostic potential of ADGRF5 in osteoporosis and cancers, and ongoing studies suggest other diseases as well. Here, we elaborate on the current state of knowledge about the ADGRF5 in the physiology and pathophysiology of human diseases and highlight its high potential as a novel target in various therapeutic areas.

Original language	English
Article number	166683
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1869
Issue number	5
DOIs	https://doi.org/10.1016/j.bbadis.2023.166683
State	Published - Jun 2023

Bibliographical note

Funding Information:
This work was supported by a grants ( 2019/32/C/NZ5/00064 to DJ) from the National Science Centre, Poland ; ( 6/IDUB/MLOD/2021 to DJ) from the University of Lodz, Poland; ( R01CA207051 to EJB) from the National Cancer Institute , USA and statutory funds of the Department of Biochemistry, Faculty of Medicine, Medical University of Lodz , Poland ( 503/1-156-04/503-11-001-19 to JF).

Funding Information:
DJ was supported by the Foundation for Polish Science (FNP, START 30.2021 ).

Publisher Copyright:
© 2023 The Authors

Keywords

ADGRF5
Adhesion G protein-coupled receptor
Adhesion G protein-coupled receptor F5
G protein-coupled receptor 116
GPR116
Ig-Hepta

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbadis.2023.166683

Cite this

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title = "The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancers",

abstract = "Among the numerous adhesion G protein-coupled receptors (GPCRs), adhesion G protein-coupled estrogen receptor F5 (ADGRF5) contains unique domains in the long N-terminal tail which can determine cell-cell and cell-matrix interaction as well as cell adhesion. Nevertheless, the biology of ADGRF5 is complex and still poorly explored. Accumulating evidence suggests that the ADGRF5 activity is fundamental in health and disease. For instance, ADGRF5 is essential in the proper function of lungs and kidney as well as the endocrine system, and its signification in vascularization and tumorigenesis has been demonstrated. The most recent studies have provided findings about the diagnostic potential of ADGRF5 in osteoporosis and cancers, and ongoing studies suggest other diseases as well. Here, we elaborate on the current state of knowledge about the ADGRF5 in the physiology and pathophysiology of human diseases and highlight its high potential as a novel target in various therapeutic areas.",

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note = "Funding Information: This work was supported by a grants ( 2019/32/C/NZ5/00064 to DJ) from the National Science Centre, Poland ; ( 6/IDUB/MLOD/2021 to DJ) from the University of Lodz, Poland; ( R01CA207051 to EJB) from the National Cancer Institute , USA and statutory funds of the Department of Biochemistry, Faculty of Medicine, Medical University of Lodz , Poland ( 503/1-156-04/503-11-001-19 to JF). Funding Information: DJ was supported by the Foundation for Polish Science (FNP, START 30.2021 ). Publisher Copyright: {\textcopyright} 2023 The Authors",

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AB - Among the numerous adhesion G protein-coupled receptors (GPCRs), adhesion G protein-coupled estrogen receptor F5 (ADGRF5) contains unique domains in the long N-terminal tail which can determine cell-cell and cell-matrix interaction as well as cell adhesion. Nevertheless, the biology of ADGRF5 is complex and still poorly explored. Accumulating evidence suggests that the ADGRF5 activity is fundamental in health and disease. For instance, ADGRF5 is essential in the proper function of lungs and kidney as well as the endocrine system, and its signification in vascularization and tumorigenesis has been demonstrated. The most recent studies have provided findings about the diagnostic potential of ADGRF5 in osteoporosis and cancers, and ongoing studies suggest other diseases as well. Here, we elaborate on the current state of knowledge about the ADGRF5 in the physiology and pathophysiology of human diseases and highlight its high potential as a novel target in various therapeutic areas.

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The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancers

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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