The common metabolite glycerol-3-phosphate is a novel regulator of plant defense signaling

Srivathsa C. Venugopal; Bidisha Chanda; Lisa Vaillancourt; Aardra Kachroo; Pradeep Kachroo

doi:10.4161/psb.4.8.9111

The common metabolite glycerol-3-phosphate is a novel regulator of plant defense signaling

Srivathsa C. Venugopal, Bidisha Chanda, Lisa Vaillancourt, Aardra Kachroo, Pradeep Kachroo

Plant Pathology

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Conversion of glycerol to glycerol-3-phosphate (G3P) is one of the highly conserved steps of glycerol metabolism in evolutionary diverse organisms. In plants, G3P is produced either via the glyc- erol kinase (GK)-mediated phosphorylation of glycerol, or via G3P dehydrogenase (G3Pdh)-mediated reduction of dihydroxy- acetone phosphate (DHAP). We have recently shown that G3P levels contribute to basal resistance against the hemibiotrophic pathogen, Colletotrichum higginsianum. Since a mutation in the GLY1-encoded G3Pdh conferred more susceptibility compared to a mutation in the GLI1-encoded GK, we proposed that GLY1 is the major contributor of the total G3P pool that participates in defense against C. higginsianum.

Original language	English
Pages (from-to)	746-749
Number of pages	4
Journal	Plant Signaling and Behavior
Volume	4
Issue number	8
DOIs	https://doi.org/10.4161/psb.4.8.9111
State	Published - 2009

Bibliographical note

Funding Information:
This work was supported by grants from the USDA-NRI (2004-03287, 2006-01854), NSF (MCB#0421914, IOS#0749731) and the Kentucky Science and Engineering Foundation (622-RDE-006).

Funding

This work was supported by grants from the USDA-NRI (2004-03287, 2006-01854), NSF (MCB#0421914, IOS#0749731) and the Kentucky Science and Engineering Foundation (622-RDE-006).

Funders	Funder number
NRI/CSREES/USDA	2006-01854, 2004-03287
National Science Foundation (NSF)	0749731, 0421914
Kentucky Science and Engineering Foundation	622-RDE-006

Keywords

Defense
Glycerol metabolism
Glycerol-3-phosphate
Signaling

ASJC Scopus subject areas

Plant Science

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10.4161/psb.4.8.9111

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title = "The common metabolite glycerol-3-phosphate is a novel regulator of plant defense signaling",

abstract = "Conversion of glycerol to glycerol-3-phosphate (G3P) is one of the highly conserved steps of glycerol metabolism in evolutionary diverse organisms. In plants, G3P is produced either via the glyc- erol kinase (GK)-mediated phosphorylation of glycerol, or via G3P dehydrogenase (G3Pdh)-mediated reduction of dihydroxy- acetone phosphate (DHAP). We have recently shown that G3P levels contribute to basal resistance against the hemibiotrophic pathogen, Colletotrichum higginsianum. Since a mutation in the GLY1-encoded G3Pdh conferred more susceptibility compared to a mutation in the GLI1-encoded GK, we proposed that GLY1 is the major contributor of the total G3P pool that participates in defense against C. higginsianum.",

keywords = "Defense, Glycerol metabolism, Glycerol-3-phosphate, Signaling",

author = "Venugopal, \{Srivathsa C.\} and Bidisha Chanda and Lisa Vaillancourt and Aardra Kachroo and Pradeep Kachroo",

note = "Funding Information: This work was supported by grants from the USDA-NRI (2004-03287, 2006-01854), NSF (MCB\#0421914, IOS\#0749731) and the Kentucky Science and Engineering Foundation (622-RDE-006).",

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AU - Venugopal, Srivathsa C.

AU - Chanda, Bidisha

AU - Vaillancourt, Lisa

AU - Kachroo, Aardra

AU - Kachroo, Pradeep

N1 - Funding Information: This work was supported by grants from the USDA-NRI (2004-03287, 2006-01854), NSF (MCB#0421914, IOS#0749731) and the Kentucky Science and Engineering Foundation (622-RDE-006).

PY - 2009

Y1 - 2009

N2 - Conversion of glycerol to glycerol-3-phosphate (G3P) is one of the highly conserved steps of glycerol metabolism in evolutionary diverse organisms. In plants, G3P is produced either via the glyc- erol kinase (GK)-mediated phosphorylation of glycerol, or via G3P dehydrogenase (G3Pdh)-mediated reduction of dihydroxy- acetone phosphate (DHAP). We have recently shown that G3P levels contribute to basal resistance against the hemibiotrophic pathogen, Colletotrichum higginsianum. Since a mutation in the GLY1-encoded G3Pdh conferred more susceptibility compared to a mutation in the GLI1-encoded GK, we proposed that GLY1 is the major contributor of the total G3P pool that participates in defense against C. higginsianum.

AB - Conversion of glycerol to glycerol-3-phosphate (G3P) is one of the highly conserved steps of glycerol metabolism in evolutionary diverse organisms. In plants, G3P is produced either via the glyc- erol kinase (GK)-mediated phosphorylation of glycerol, or via G3P dehydrogenase (G3Pdh)-mediated reduction of dihydroxy- acetone phosphate (DHAP). We have recently shown that G3P levels contribute to basal resistance against the hemibiotrophic pathogen, Colletotrichum higginsianum. Since a mutation in the GLY1-encoded G3Pdh conferred more susceptibility compared to a mutation in the GLI1-encoded GK, we proposed that GLY1 is the major contributor of the total G3P pool that participates in defense against C. higginsianum.

KW - Defense

KW - Glycerol metabolism

KW - Glycerol-3-phosphate

KW - Signaling

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ER -

The common metabolite glycerol-3-phosphate is a novel regulator of plant defense signaling

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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