TY - JOUR
T1 - The context‐dependent impact of integrin‐associated cd151 and other tetraspanins on cancer development and progression
T2 - A class of versatile mediators of cellular function and signaling, tumorigenesis and metastasis
AU - Erfani, Sonia
AU - Hua, Hui
AU - Pan, Yueyin
AU - Zhou, Binhua P.
AU - Yang, Xiuwei H.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - As a family of integral membrane proteins, tetraspanins have been functionally linked to a wide spectrum of human cancers, ranging from breast, colon, lung, ovarian, prostate, and skin carcinomas to glioblastoma. CD151 is one such prominent member of the tetraspanin family recently suggested to mediate tumor development, growth, and progression in oncogenic context-and cell lineage‐dependent manners. In the current review, we summarize recent advances in mechanistic understanding of the function and signaling of integrin‐associated CD151 and other tetraspanins in multiple cancer types. We also highlight emerging genetic and epigenetic evidence on the intrinsic links between tetraspanins, the epithelial‐mesenchymal transition (EMT), cancer stem cells (CSCs), and the Wnt/β‐catenin pathway, as well as the dynamics of exosome and cellular metabolism. Finally, we discuss the implications of the highly plastic nature and epigenetic susceptibility of CD151 expression, function, and signaling for clinical diagnosis and therapeutic intervention for human cancer.
AB - As a family of integral membrane proteins, tetraspanins have been functionally linked to a wide spectrum of human cancers, ranging from breast, colon, lung, ovarian, prostate, and skin carcinomas to glioblastoma. CD151 is one such prominent member of the tetraspanin family recently suggested to mediate tumor development, growth, and progression in oncogenic context-and cell lineage‐dependent manners. In the current review, we summarize recent advances in mechanistic understanding of the function and signaling of integrin‐associated CD151 and other tetraspanins in multiple cancer types. We also highlight emerging genetic and epigenetic evidence on the intrinsic links between tetraspanins, the epithelial‐mesenchymal transition (EMT), cancer stem cells (CSCs), and the Wnt/β‐catenin pathway, as well as the dynamics of exosome and cellular metabolism. Finally, we discuss the implications of the highly plastic nature and epigenetic susceptibility of CD151 expression, function, and signaling for clinical diagnosis and therapeutic intervention for human cancer.
KW - Breast cancer
KW - CD151
KW - Cancer stem cells
KW - Epithelial‐mesenchymal transition (EMT)
KW - Exosome
KW - Integrins
KW - Tetraspanins
KW - Wnt pathway
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U2 - 10.3390/cancers13092005
DO - 10.3390/cancers13092005
M3 - Review article
AN - SCOPUS:85104405072
SN - 2072-6694
VL - 13
JO - Cancers
JF - Cancers
IS - 9
M1 - 2005
ER -