The contributing role of lipid peroxidation and protein oxidation in the course of CNS injury neurodegeneration and neuroprotection: An overview

Edward D. Hall

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

23 Scopus citations

Abstract

At present, there are no FDA-approved pharmacological therapies for acute treatment of traumatic brain injury (TBI) patients that are conclusively proven to mitigate the often devastating neurological effects of their injuries. Nevertheless, the possibility of an effective neuroprotective treatment is based upon the fact that even though some of the neural injury is due to the primary mechanical events (i.e., shearing of nerve cells and blood vessels), the majority of posttraumatic neurodegeneration is due to a pathomolecular and pathophysiological secondary cascade that occurs during the first minutes, hours and days following the injury which exacerbates the damaging effects of the primary injury. One of the most validated “secondary injury” mechanisms revealed in experimental TBI studies involves oxygen radical-induced oxidative damage to brain cell lipids and proteins. This chapter outlines the key sources of reactive oxygen species (ROS) including highly reactive (i.e., rapidly oxidizing) free radicals, the mechanisms associated with their neural damage, pharmacological scavenging antioxidants that have been shown to produce neuroprotective effect in TBI models and brief mention of the most widely used methods for studying the extent of lipid and protein oxidative damage in TBI models.

Original languageEnglish
Title of host publicationBrain Neurotrauma
Subtitle of host publicationMolecular, Neuropsychological, and Rehabilitation Aspects
Pages49-60
Number of pages12
ISBN (Electronic)9781466565999
DOIs
StatePublished - Jan 1 2015

Bibliographical note

Publisher Copyright:
© 2015 by Taylor & Francis Group, LLC.

ASJC Scopus subject areas

  • General Neuroscience
  • General Medicine

Fingerprint

Dive into the research topics of 'The contributing role of lipid peroxidation and protein oxidation in the course of CNS injury neurodegeneration and neuroprotection: An overview'. Together they form a unique fingerprint.

Cite this