The contribution of inflammation to Alzheimer’s disease in Down syndrome

Alessandra C. Martini, Courtney Kloske, Donna M. Wilcock, Elizabeth Head

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Down syndrome (DS), the most common genetic cause of intellectual disability, is characterized by the triplication of chromosome 21. The triplication of the amyloid precursor protein gene, amyloid precursor protein (APP), is thought to be the underlying reason why Alzheimer’s disease (AD) pathology develops in the DS brain with age. In this chapter, we explore the neuroinflammatory consequences of AD pathology in the brain, and how this may be unique in DS due to the triplication of immune-associated genes also located on chromosome 21.

Original languageEnglish
Title of host publicationThe Neurobiology of Aging and Alzheimer Disease in Down Syndrome
Pages45-62
Number of pages18
ISBN (Electronic)9780128188453
DOIs
StatePublished - Jan 1 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.

Keywords

  • Beta-amyloid
  • Biomarkers
  • Chemokines
  • Cytokines
  • Microglia
  • Therapeutics

ASJC Scopus subject areas

  • Medicine (all)

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