Down syndrome (DS), the most common genetic cause of intellectual disability, is characterized by the triplication of chromosome 21. The triplication of the amyloid precursor protein gene, amyloid precursor protein (APP), is thought to be the underlying reason why Alzheimer’s disease (AD) pathology develops in the DS brain with age. In this chapter, we explore the neuroinflammatory consequences of AD pathology in the brain, and how this may be unique in DS due to the triplication of immune-associated genes also located on chromosome 21.
|Title of host publication||The Neurobiology of Aging and Alzheimer Disease in Down Syndrome|
|Number of pages||18|
|State||Published - Jan 1 2021|
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ASJC Scopus subject areas
- Medicine (all)