The contribution of inflammation to Alzheimer’s disease in Down syndrome

Alessandra C. Martini; Courtney Kloske; Donna M. Wilcock; Elizabeth Head

doi:10.1016/B978-0-12-818845-3.00016-5

The contribution of inflammation to Alzheimer’s disease in Down syndrome

Alessandra C. Martini, Courtney Kloske, Donna M. Wilcock, Elizabeth Head

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Down syndrome (DS), the most common genetic cause of intellectual disability, is characterized by the triplication of chromosome 21. The triplication of the amyloid precursor protein gene, amyloid precursor protein (APP), is thought to be the underlying reason why Alzheimer’s disease (AD) pathology develops in the DS brain with age. In this chapter, we explore the neuroinflammatory consequences of AD pathology in the brain, and how this may be unique in DS due to the triplication of immune-associated genes also located on chromosome 21.

Original language	English
Title of host publication	The Neurobiology of Aging and Alzheimer Disease in Down Syndrome
Pages	45-62
Number of pages	18
ISBN (Electronic)	9780128188453
DOIs	https://doi.org/10.1016/B978-0-12-818845-3.00016-5
State	Published - Jan 1 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.

Keywords

Beta-amyloid
Biomarkers
Chemokines
Cytokines
Microglia
Therapeutics

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-818845-3.00016-5

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abstract = "Down syndrome (DS), the most common genetic cause of intellectual disability, is characterized by the triplication of chromosome 21. The triplication of the amyloid precursor protein gene, amyloid precursor protein (APP), is thought to be the underlying reason why Alzheimer{\textquoteright}s disease (AD) pathology develops in the DS brain with age. In this chapter, we explore the neuroinflammatory consequences of AD pathology in the brain, and how this may be unique in DS due to the triplication of immune-associated genes also located on chromosome 21.",

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AB - Down syndrome (DS), the most common genetic cause of intellectual disability, is characterized by the triplication of chromosome 21. The triplication of the amyloid precursor protein gene, amyloid precursor protein (APP), is thought to be the underlying reason why Alzheimer’s disease (AD) pathology develops in the DS brain with age. In this chapter, we explore the neuroinflammatory consequences of AD pathology in the brain, and how this may be unique in DS due to the triplication of immune-associated genes also located on chromosome 21.

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KW - Biomarkers

KW - Chemokines

KW - Cytokines

KW - Microglia

KW - Therapeutics

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BT - The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

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The contribution of inflammation to Alzheimer’s disease in Down syndrome

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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