The cytolethal distending toxin family

Carol L. Pickett, Chris A. Whitehouse

Research output: Contribution to journalReview articlepeer-review

203 Scopus citations


Cytolethal distending toxins are produced by a small but diverse group of bacterial pathogens. This newly discovered toxin family can cause a variety of mammalian cells to become irreversibly blocked in the G2 phase of the cell cycle. How this novel effect is accomplished is unknown but the study of these fascinating toxins promises to reveal new methods of host-pathogen interaction. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)292-297
Number of pages6
JournalTrends in Microbiology
Issue number7
StatePublished - Jul 1 1999

Bibliographical note

Funding Information:
We thank Eric Hansen, James Kaper, Lawrence Dreyfus, Eric Oswald, Nancy Strockbine and Daniel Scott for stimulating discussions and the NIH for financial support (AI41477).

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases


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