Abstract
Dendrite morphogenesis is a complex but well-orchestrated process and includes the development of dendritic branches, forming characteristic dendrite arbors, and dendritic spines, allowing neurons to communicate with each other. Various studies report that many neuropsychiatric disorders are characterized by dendritic and synaptic pathology, including abnormal spine density and morphology, synapse loss, and aberrant synaptic signaling and plasticity. In this review, we discuss dendrite development and branching, and in specific, morphology, cytoskeletal architecture, and how the complexity of the dendrite tree and its functional capabilities are altered in various brain disorders. Identifying and understanding these changes in dendrite morphology are essential for understanding brain function in normal and disease states.
| Original language | English |
|---|---|
| Pages (from-to) | 10-20 |
| Number of pages | 11 |
| Journal | Molecular and Cellular Neuroscience |
| Volume | 50 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 2012 |
Funding
This work was supported in part by NSF grant IBN-0919747 , March of Dimes Foundation Grant 1-FY08-464 , and NJ Governor's Council for Medical Research and Treatment of Autism grant 10-406-SCH-E-0 (to B.L.F.). We thank members of the Firestein laboratory for their comments on the manuscript.
| Funders | Funder number |
|---|---|
| Council for Medical Research and Treatment of Autism | 10-406-SCH-E-0 |
| National Science Foundation | IBN-0919747 |
| March of Dimes Research Foundation | 1-FY08-464 |
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
- Cell Biology
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