The dependence of viral RNA replication on co-opted host factors

Peter D. Nagy; Judit Pogany

doi:10.1038/nrmicro2692

The dependence of viral RNA replication on co-opted host factors

Peter D. Nagy, Judit Pogany

Plant Pathology

Research output: Contribution to journal › Review article › peer-review

328 Scopus citations

Abstract

Positive-sense RNA ((+)RNA) viruses such as hepatitis C virus exploit host cells by subverting host proteins, remodelling subcellular membranes, co-opting and modulating protein and ribonucleoprotein complexes, and altering cellular metabolic pathways during infection. To facilitate RNA replication, (+)RNA viruses interact with numerous host molecules through protein-protein, RNA-protein and protein-lipid interactions. These interactions lead to the formation of viral replication complexes, which produce new viral RNA progeny in host cells. This Review presents the recent progress that has been made in understanding the role of co-opted host proteins and membranes during (+)RNA virus replication, and discusses common themes employed by different viruses.

Original language	English
Pages (from-to)	137-149
Number of pages	13
Journal	Nature Reviews Microbiology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1038/nrmicro2692
State	Published - Feb 2012

Bibliographical note

Funding Information:
89. Knoops, K. et al. SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum. PLoS Biol. 6, e226 (2008). This study uses electron tomography and three-dimensional imaging to show coronavirus-induced DMVs.

ASJC Scopus subject areas

Microbiology
Immunology and Microbiology (all)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrmicro2692

Cite this

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abstract = "Positive-sense RNA ((+)RNA) viruses such as hepatitis C virus exploit host cells by subverting host proteins, remodelling subcellular membranes, co-opting and modulating protein and ribonucleoprotein complexes, and altering cellular metabolic pathways during infection. To facilitate RNA replication, (+)RNA viruses interact with numerous host molecules through protein-protein, RNA-protein and protein-lipid interactions. These interactions lead to the formation of viral replication complexes, which produce new viral RNA progeny in host cells. This Review presents the recent progress that has been made in understanding the role of co-opted host proteins and membranes during (+)RNA virus replication, and discusses common themes employed by different viruses.",

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AB - Positive-sense RNA ((+)RNA) viruses such as hepatitis C virus exploit host cells by subverting host proteins, remodelling subcellular membranes, co-opting and modulating protein and ribonucleoprotein complexes, and altering cellular metabolic pathways during infection. To facilitate RNA replication, (+)RNA viruses interact with numerous host molecules through protein-protein, RNA-protein and protein-lipid interactions. These interactions lead to the formation of viral replication complexes, which produce new viral RNA progeny in host cells. This Review presents the recent progress that has been made in understanding the role of co-opted host proteins and membranes during (+)RNA virus replication, and discusses common themes employed by different viruses.

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The dependence of viral RNA replication on co-opted host factors

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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