The dependence of viral RNA replication on co-opted host factors

Peter D. Nagy, Judit Pogany

Research output: Contribution to journalReview articlepeer-review

328 Scopus citations


Positive-sense RNA ((+)RNA) viruses such as hepatitis C virus exploit host cells by subverting host proteins, remodelling subcellular membranes, co-opting and modulating protein and ribonucleoprotein complexes, and altering cellular metabolic pathways during infection. To facilitate RNA replication, (+)RNA viruses interact with numerous host molecules through protein-protein, RNA-protein and protein-lipid interactions. These interactions lead to the formation of viral replication complexes, which produce new viral RNA progeny in host cells. This Review presents the recent progress that has been made in understanding the role of co-opted host proteins and membranes during (+)RNA virus replication, and discusses common themes employed by different viruses.

Original languageEnglish
Pages (from-to)137-149
Number of pages13
JournalNature Reviews Microbiology
Issue number2
StatePublished - Feb 2012

Bibliographical note

Funding Information:
89. Knoops, K. et al. SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum. PLoS Biol. 6, e226 (2008). This study uses electron tomography and three-dimensional imaging to show coronavirus-induced DMVs.

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology (all)
  • Infectious Diseases


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