The development and validation of a comorbidity index for prostate cancer among Black men

Steven T. Fleming, Kevin A. Pearce, Kathleen McDavid, Dmitri Pavlov

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background and Objectives: The purpose of this study was to develop a comorbidity index specific to Black Men with prostate cancer, because certain comorbidities and prostate cancer are particularly prevalent among this racial group. Methods: This research used the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database to develop an index of comorbidity burden based on survival, and the presence/absence of comorbid illness in 2,931 Black males diagnosed with prostate cancer. Comorbidity burden was recognized using inpatient, outpatient, and physician claims for a 2-year period prior to the diagnosis of prostate cancer. We compared five different statistical models, each with two-way, three-way, and/or four-way interactions among the comorbidities, and selected the model with only two-way interactions as the optimal choice. We demonstrated the utility of refining the simplest model, with 27 comorbidity categories only, by adjusting for the number of different diagnoses within statistically significant categories.

Original languageEnglish
Pages (from-to)1064-1075
Number of pages12
JournalJournal of Clinical Epidemiology
Issue number11
StatePublished - Nov 2003


  • Administrative data
  • Claims data
  • Comorbidity
  • Medicare
  • Prostate cancer
  • Survival analysis

ASJC Scopus subject areas

  • Epidemiology


Dive into the research topics of 'The development and validation of a comorbidity index for prostate cancer among Black men'. Together they form a unique fingerprint.

Cite this