TY - JOUR
T1 - The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications
AU - Hazra, Tapas K.
AU - Izumi, Tadahide
AU - Kow, Y. Wah
AU - Mitra, Sankar
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Oxidatively damaged bases in the genome are likely to be responsible for mutations leading to sporadic carcinogenesis. Two structurally similar DNA glycosylases, NTH1 and OGG1, which are able to excise most of these damaged bases, were identified previously in mammalian cells. A distinct family, consisting of two human DNA glycosylases orthologous to enzymes in Escherichia coli, has recently been characterized; they have overlapping substrate ranges with NTH1 and OGG1. The presence of multiple enzymes with potential back-up functions underscores the importance of removing both endogenously and exogenously generated oxidatively damaged bases from the genome, and may explain why no cancer or other disease phenotype has so far been linked to the deficiency of a single DNA glycosylase.
AB - Oxidatively damaged bases in the genome are likely to be responsible for mutations leading to sporadic carcinogenesis. Two structurally similar DNA glycosylases, NTH1 and OGG1, which are able to excise most of these damaged bases, were identified previously in mammalian cells. A distinct family, consisting of two human DNA glycosylases orthologous to enzymes in Escherichia coli, has recently been characterized; they have overlapping substrate ranges with NTH1 and OGG1. The presence of multiple enzymes with potential back-up functions underscores the importance of removing both endogenously and exogenously generated oxidatively damaged bases from the genome, and may explain why no cancer or other disease phenotype has so far been linked to the deficiency of a single DNA glycosylase.
UR - http://www.scopus.com/inward/record.url?scp=0037325763&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037325763&partnerID=8YFLogxK
U2 - 10.1093/carcin/24.2.155
DO - 10.1093/carcin/24.2.155
M3 - Article
C2 - 12584162
AN - SCOPUS:0037325763
SN - 0143-3334
VL - 24
SP - 155
EP - 157
JO - Carcinogenesis
JF - Carcinogenesis
IS - 2
ER -