The drug-loaded intracellular pH sensitive polymeric micelles

Y. S. Bae, S. Fukushima, K. Kataoka

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


The drug-loaded pH sensitive polymeric micelles from amphiphilic block copolymers poly ethylene glycol poly was reported where the anticancer drugs Adriamycin were bound through acid-cleavable hydrazone bonds. The micelles were prepared as an intelligent drug carrier for cancer treatment with enhanced drug efficiency but reduced toxicity by intracellular site-specific drug release control. It was observed that when the cells were incubated with the micelles, fluorescence intensity was changed time-dependently. The results were consistent with pH and time-dependent drug release profile, which suggested the intracellular drug release from the micelles responding to pH change in endosomal and/or lysosomal compartment in the cell.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress


ConferenceTransactions - 7th World Biomaterials Congress

ASJC Scopus subject areas

  • General Engineering


Dive into the research topics of 'The drug-loaded intracellular pH sensitive polymeric micelles'. Together they form a unique fingerprint.

Cite this