TY - GEN
T1 - The drug-loaded intracellular pH sensitive polymeric micelles
AU - Bae, Y. S.
AU - Fukushima, S.
AU - Kataoka, K.
PY - 2004
Y1 - 2004
N2 - The drug-loaded pH sensitive polymeric micelles from amphiphilic block copolymers poly ethylene glycol poly was reported where the anticancer drugs Adriamycin were bound through acid-cleavable hydrazone bonds. The micelles were prepared as an intelligent drug carrier for cancer treatment with enhanced drug efficiency but reduced toxicity by intracellular site-specific drug release control. It was observed that when the cells were incubated with the micelles, fluorescence intensity was changed time-dependently. The results were consistent with pH and time-dependent drug release profile, which suggested the intracellular drug release from the micelles responding to pH change in endosomal and/or lysosomal compartment in the cell.
AB - The drug-loaded pH sensitive polymeric micelles from amphiphilic block copolymers poly ethylene glycol poly was reported where the anticancer drugs Adriamycin were bound through acid-cleavable hydrazone bonds. The micelles were prepared as an intelligent drug carrier for cancer treatment with enhanced drug efficiency but reduced toxicity by intracellular site-specific drug release control. It was observed that when the cells were incubated with the micelles, fluorescence intensity was changed time-dependently. The results were consistent with pH and time-dependent drug release profile, which suggested the intracellular drug release from the micelles responding to pH change in endosomal and/or lysosomal compartment in the cell.
UR - http://www.scopus.com/inward/record.url?scp=13844254053&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13844254053&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:13844254053
SN - 1877040193
SN - 9781877040191
T3 - Transactions - 7th World Biomaterials Congress
SP - 1167
BT - Transactions - 7th World Biomaterials Congress
T2 - Transactions - 7th World Biomaterials Congress
Y2 - 17 May 2004 through 21 May 2004
ER -