The early impact of genetics on our understanding of cell cycle regulation in Aspergillus nidulans

Stephen A. Osmani, Peter M. Mirabito

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

The application of genetic analysis was crucial to the rapid progress that has been made in cell cycle research. Ron Morris, one of the first to apply genetics to cell cycle research, developed Aspergillus nidulans into an important model system for the analysis of many aspects of cell biology. Within the area of cell cycle research, Ron's laboratory is noted for development of novel cell biological and molecular genetic approaches as well as seminal insights regarding the regulation of mitosis, checkpoint regulation of the cell cycle, and the role of microtubule-based motors in chromosome segregation. In this special edition of FGB dedicated to Ron Morris, and in light of the recent progress in fungal genomics, we review the outstanding contributions his work made to our understanding of mitotic regulation. Indeed, his efforts have provided many mutants and experimental tools along with the conceptual framework for current and future studies of mitosis in A. nidulans.

Original languageEnglish
Pages (from-to)401-410
Number of pages10
JournalFungal Genetics and Biology
Volume41
Issue number4
DOIs
StatePublished - Apr 2004

Bibliographical note

Funding Information:
We thank Colin De Souza and Jonathan Davis for critically reading this review. We also thank Venu Gopal-Puram for significant contributions to the multiblast analysis of the A. nidulans , S. cerevisiae , and S. pombe genomes and Chuck Staben for insightful discussions of the bioinformatic data. The bioinformatic analysis was supported by Grant 5P20RR016481-03 from the National Institutes of Health. SAO is supported by Grant GM-42564 from the National Institutes of Health.

ASJC Scopus subject areas

  • Microbiology
  • Genetics

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