The Early Osteoarthritic Knee: Implications for Cartilage Repair

Chaitu Malempati, Cale A. Jacobs, Christian Lattermann

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Patients with early osteoarthritis (OA) have been reported to have inferior outcomes with an increased prevalence of early failure after cartilage procedures. The underlying reasons for this failure are likely multifactorial, including a chronic synovial and chondrogenic process, which is confounded by persistent muscle weakness and altered pain processing for those with increased preoperative symptom duration. Pain, radiographic changes, patient-reported outcomes, and macroscopic changes on arthroscopic evaluation or MRI can assist clinicians in identifying the early OA knee to both aid in clinical decision making and create realistic postoperative expectations for patients.

Original languageEnglish
Pages (from-to)587-596
Number of pages10
JournalClinics in Sports Medicine
Issue number3
StatePublished - Jul 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.


  • Articular cartilage
  • Body mass index
  • Bone marrow lesion
  • Cartilage defect
  • Extracellular matrix
  • Knee
  • Osteoarthritis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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